2,080 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Genomic and phenotypic evolution of Escherichia coli in a novel citrate-only resource environment

    Zachary D Blount et al.
    Transposable elements and gene amplifications can provide variation needed for novel trait refinement and adaptation to new niches, though a recalcitrant organism-environment mismatch may persist.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome

    Andrew B Morgenthaler et al.
    Mutations elsewhere in the genome play critical roles in improving fitness during amplification and divergence of a gene encoding a weak-link enzyme whose inefficiency limits growth rate.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    The autoregulation of a eukaryotic DNA transposon

    Corentin Claeys Bouuaert et al.
    A DNA transposon, or ‘jumping gene’, controls its amplification within a genome through a competition between the enzyme multimers that are responsible for its mobility.
    1. Chromosomes and Gene Expression

    Genome Organization: Painting chromosomes in the nucleus

    Cori K Cahoon, Diana E Libuda
    A multiplexed approach to DNA FISH experiments has been used to visualize the three-dimensional organization of chromosomes and specific chromosomal regions in C. elegans..
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    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Science Forum: Addressing selective reporting of experiments through predefined exclusion criteria

    Kleber Neves, Olavo B Amaral
    Researchers should define in advance the criteria for excluding the results of experiments that 'did not work' from articles.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Reproducibility in Cancer Biology: Getting to grips with c-Myc

    Dirk Eick
    The transcription factor c-Myc amplifies the transcription of many growth-related genes in cancer cells, but its role as an oncogene is not fully understood.
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    1. Cell Biology
    2. Evolutionary Biology

    Phylogenomics: Leaving negative ancestors behind

    Sergio A Muñoz-Gómez, Andrew J Roger
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    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Fossils: A new home for microbes

    Raphael Eisenhofer, Alan Cooper
    Modern microorganisms growing in fossils provide major challenges for researchers trying to detect ancient molecules in the same fossils.
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