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Page 4 of 178
    1. Neuroscience

    Corollary discharge promotes a sustained motor state in a neural circuit for navigation

    Ni Ji et al.
    A primary sensory interneuron in the thermotaxis circuit of C. elegans integrates sensory input and corollary discharge to drive persistent navigational states and movement towards preferred environments.
    1. Cancer Biology

    Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

    Alba Nicolas-Boluda et al.
    Tumor stiffness blocks T cell migration in tumors.
    1. Cell Biology

    An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish

    Dianne Lumaquin et al.
    A novel transgenic lipid droplet reporter in transparent casper zebrafish allows direct visualization of individual lipid droplets in a living animal.
    1. Neuroscience

    Temporally delayed linear modelling (TDLM) measures replay in both animals and humans

    Yunzhe Liu et al.
    Temporally delayed linear modelling provides a domain-general linear framework for sequence detection and statistical testing, and is able to detect replays in both human neuroimaging and animal electrophysiology.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Spatially compartmentalized phase regulation of a Ca2+-cAMP-PKA oscillatory circuit

    Brian Tenner et al.
    Nanodomain clustering of cAMP effectors represents a novel mechanism of cAMP compartmentation within an oscillatory signaling circuit.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanistic insights into volatile anesthetic modulation of K2P channels

    Aboubacar Wague et al.
    The volatile anesthetic isoflurane directly binds to the transmembrane domains of the TREK1 channel to allosterically modulate its function.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Atomic structure of a mitochondrial complex I intermediate from vascular plants

    Maria Maldonado et al.
    The first atomic resolution structure of a mitochondrial respiratory complex from plants provides insight into the assembly and evolution of respiration in autotrophic eukaryotes.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Chromosome organization by one-sided and two-sided loop extrusion

    Edward J Banigan et al.
    Seemingly contradictory findings of single-molecule and in vivo experiments on a major mechanism of chromosome organization are reconciled by computationally investigating mechanisms of loop extrusion that are consistent with both.
    1. Cell Biology
    2. Neuroscience

    Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons

    Chantell S Evans, Erika LF Holzbaur
    In neuronal mitophagy, Parkin and OPTN induce efficient sequestration of damaged somal mitochondria into autophagosomes, but slow turnover via lysosomal acidification may be a point of vulnerability for the cell.
    1. Biochemistry and Chemical Biology

    Inhibition of synucleinopathic seeding by rationally designed inhibitors

    Smriti Sangwan et al.
    Inhibitors of seeded propagation of alpha-synuclein may be developed into diagnostics and therapeutics for Parkinson's disease.