Browse the search results

Page 4 of 175
    1. Chromosomes and Gene Expression

    Conversion of random X-inactivation to imprinted X-inactivation by maternal PRC2

    Clair Harris et al.
    The PRC2 Polycomb complex made in the mouse oocyte prevents transcriptional inactivation of the maternal X-chromosome in the early embryo.
    1. Stem Cells and Regenerative Medicine

    Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis

    Isabelle Bergiers et al.
    Single-cell transcriptomics analysis identifies the dynamic activity of transcription factors at the onset of hematopoeitic stem and progenitor cells formation during embryonic development.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Rad52-Rad51 association is essential to protect Rad51 filaments against Srs2, but facultative for filament formation

    Emilie Ma et al.
    The association of Rad52 with Rad51, while not critical for Rad51 filament formation, is crucial to protect Rad51 filaments from Srs2 translocase activity through the association of Rad52 with complete Rad51 filaments.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons

    Chongyuan Luo et al.
    Induced neuronal cells acquire epigenomic signatures specific to matured neurons.
    1. Epidemiology and Global Health

    The Anopheles gambiae 2La chromosome inversion is associated with susceptibility to Plasmodium falciparum in Africa

    Michelle M Riehle et al.
    A common chromosome inversion in African malaria mosquito (Anopheles gambiae) is associated with differences in malaria infection, adult resting behavior and ecology, and may aid the most efficient vectors to evade malaria control.
    1. Cell Biology
    2. Immunology and Inflammation

    Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein

    Jean-Marie Buerstedde et al.
    Intra- and intergenic deletions by repeat recombination broaden the mutagenic potential of the activation induced cytidine deaminase (AID) protein.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The yeast mating-type switching endonuclease HO is a domesticated member of an unorthodox homing genetic element family

    Aisling Y Coughlan et al.
    A family of homing genetic elements that look like inteins but work differently is the progenitor of the endonuclease that enables Saccharomyces cerevisiae to change its mating type.
    1. Cell Biology
    2. Developmental Biology

    Temporospatial induction of homeodomain gene cut dictates natural lineage reprogramming

    Ke Xu et al.
    Spatial and temporal cues intersect, likely via enhancer-promoter looping, to turn on a master identity switch that in turn dictates natural lineage reprogramming with high efficiency and temporospatial precision.
    1. Chromosomes and Gene Expression

    Sustained TNF-α stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness

    Zuodong Zhao et al.
    Sustained TNF-α induction consolidates transcriptional memory for faster, stronger, and more sensitive subsequent induction in an active DNA demethylation-dependent manner for memory genes including CALCB, a therapeutic target for migraine.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    In-host population dynamics of Mycobacterium tuberculosis complex during active disease

    Roger Vargas et al.
    Bulk whole genome sequencing data can be used to study the genetic variation present in pathogenic bacterial populations over the time-course of a single infection within a host.