PRUNE2/PCA3 axis dysregulation is an early, rather than late, event in prostate cancer tumorigenesis.

Based on benchmarking various methods and analyzing multiple real scRNA-seq datasets, a computational platform/workflow and a set of tips for best practices are developed for analyzing causal interactions or relationships in single cells.

Editors' Summary: This Replication Study has reproduced important parts of the original paper.

Bioinformatic analysis of gene expression in chimeric heterokaryons can identify novel regulators of cell lineage.

Multiple replicated examples of epistasis affecting gene expression in humans are identified, some explaining a substantial proportion of the variation in expression.

Integration of automatic behavioral tracking with brain molecular profiling reveals the role of gene regulatory network plasticity in the regulation of behavioral phenotypes.

Extending the period of remission for cancer patients requires new knowledge of dormant, residual disease and Netrin signaling contributes to the survival of dormant cells in ovarian cancer.

Comprehensive analysis of alternative splicing from human droplet-based scRNA-seq data identifies genes with regulated splicing conserved in mouse and mouse lemur.

A new gene expression tool enables precise control of protein dosage over a large range and paves the way for new genetic discoveries.