4,688 results found
    1. Ecology
    2. Chromosomes and Gene Expression

    Emerging Technology: Concerning RNA-guided gene drives for the alteration of wild populations

    Kevin M Esvelt et al.
    Combining CRISPR/Cas9 genome editing with gene drives may enable scientists to reversibly edit the genomes of diverse wild populations, an advance that could help eliminate diseases, support sustainable agriculture, and control invasive species.
    1. Epidemiology and Global Health

    Development of a confinable gene drive system in the human disease vector Aedes aegypti

    Ming Li et al.
    Highly efficient and confinable split gene drives are a new tool for the control of the dengue mosquito vector.
    1. Genetics and Genomics

    Molecular safeguarding of CRISPR gene drive experiments

    Jackson Champer et al.
    Genes drives utilizing synthetic target sites and the split-Cas9 system have similar performance to standard drives.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A Y-chromosome shredding gene drive for controlling pest vertebrate populations

    Thomas AA Prowse et al.
    A Y-chromosome shredding gene drive that depletes the pool of XY males and effects mate limitation could be a viable tool for vertebrate pest control.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Current CRISPR gene drive systems are likely to be highly invasive in wild populations

    Charleston Noble et al.
    If released in the wild, current CRISPR-based gene drive systems designed to alter populations could spread much farther than intended, despite the evolution of drive resistance.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    wtf genes are prolific dual poison-antidote meiotic drivers

    Nicole L Nuckolls et al.
    Selfish wtf meiotic drive genes use overlapping transcripts to encode both a trans-acting poison to kill gametes that do not inherit the gene and a gamete-autonomous antidote to specifically rescue the gametes that do.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Combinations of Spok genes create multiple meiotic drivers in Podospora

    Aaron A Vogan et al.
    Members of a single gene family determine the genomic basis of multiple coexisting meiotic drive elements in natural populations of Podospora.
    1. Cancer Biology

    Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

    Simeon U Springer et al.
    The creation of a non-invasive assay for detecting urothelial cancer could have a profound impact on how we find and treat the disease.
    1. Evolutionary Biology

    Genome expansion in early eukaryotes drove the transition from lateral gene transfer to meiotic sex

    Marco Colnaghi et al.
    Lateral gene transfer is unable to resist mutation accumulation in large genomes, leading to selective pressure for the origin of meiotic sex in the first eukaryotes.

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