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    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Metabolic interactions between dynamic bacterial subpopulations

    Adam Z Rosenthal, Yutao Qi ... Michael B Elowitz
    Metabolic division of labor in B. subtilis controls the extracellular environment.
    1. Plant Biology

    Cell elongation is regulated through a central circuit of interacting transcription factors in the Arabidopsis hypocotyl

    Eunkyoo Oh, Jia-Ying Zhu ... Zhi-Yong Wang
    Signals from major hormones and the environment are integrated in the Arabidopsis hypocotyl to control gene expression and plant stem elongation.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

    Anthony S Findley, Alan Monziani ... Francesca Luca
    Investigation of dynamic gene regulation across cell types and environments reveals new GxE regulatory loci that are important for disease.
    1. Computational and Systems Biology

    A large accessory protein interactome is rewired across environments

    Zhimin Liu, Darach Miller ... Sasha F Levy
    A massively multiplexed multi-condition screen shows that protein interactomes are larger than previously thought and contain highly dynamic regions that reorganize to drive or respond to cellular changes.
    1. Genetics and Genomics

    Age and diet shape the genetic architecture of body weight in diversity outbred mice

    Kevin M Wright, Andrew G Deighan ... Anil Raj
    Genetic effects on body weight in mice are highly heterogeneous, dynamic, and nonlinear with respect to genomic background, age, and diet.
    1. Genetics and Genomics
    2. Neuroscience

    Learning is enhanced by tailoring instruction to individual genetic differences

    David G Mets, Michael S Brainard
    Tailoring instructive experience to individual genetic biases improves vocal learning outcomes across genetic backgrounds in the Bengalese finch.
    1. Neuroscience

    Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior

    Mar Gacias, Sevasti Gaspari ... Patrizia Casaccia
    Gut microbiota can influence mPFC transcriptional profiles and myelin content, overriding the impact of genetic background in the development of social avoidance behavior.
    1. Genetics and Genomics

    Understanding genetic variants in context

    Nasa Sinnott-Armstrong, Stanley Fields ... Christine Queitsch
    Multiplexed assays of variant effect are an increasingly important tool in genetic research and including more context specificity in their design would aid interpretation and discovery.
    1. Microbiology and Infectious Disease

    Interactions between metabolism and growth can determine the co-existence of Staphylococcus aureus and Pseudomonas aeruginosa

    Camryn Pajon, Marla C Fortoul ... Robert P Smith
    The growth environment driven ratio of ATP to growth rate, called absolute growth, determines the final population composition of Staphylococcus aureus and Pseudomonas aeruginosa when in co-culture.
    1. Microbiology and Infectious Disease

    Changes in the genetic requirements for microbial interactions with increasing community complexity

    Manon Morin, Emily C Pierce, Rachel J Dutton
    Analysis of the global genetic requirements and gene expression changes in E. coli in the presence of a simple microbiome revealed pairwise and higher-order interactions, and underlying molecular mechanisms.