2,982 results found
    1. Cell Biology

    Exploring the role of macromolecular crowding and TNFR1 in cell volume control

    Parijat Biswas, Priyanka Roy ... Deepak Kumar Sinha
    Cells adapt to extracellular hypertonicities using regulatory volume increase (RVI), and TNFR1-mediated NFkB activation is indispensable for RVI, but the increased cytoplasmic macromolecular crowding can inhibit TNFR1 signaling and prevent RVI at severe hypertonicities.
    1. Ecology

    Role of immigrant males and muzzle contacts in the uptake of a novel food by wild vervet monkeys

    Pooja Dongre, Gaëlle Lanté ... Erica van de Waal
    New immigrants triggered fast uptake of a novel food in groupmates, who obtained information about it through muzzle contacts, opening up new questions about the role of dispersers in information flow around a population.
    1. Neuroscience

    Human endogenous oxytocin and its neural correlates show adaptive responses to social touch based on recent social context

    Linda Handlin, Giovanni Novembre ... India Morrison
    Touch-mediated social interactions in human females elicited endogenous oxytocin and brain responses in a covariant manner, and these changes were modulated by the familiarity of the person delivering touch as well as the recent history of social interaction.
    1. Computational and Systems Biology
    2. Neuroscience

    Olfactory responses of Drosophila are encoded in the organization of projection neurons

    Kiri Choi, Won Kyu Kim, Changbong Hyeon
    The organization of olfactory projection neurons and their synaptic connectivity with third-order neurons studied along with olfactory responses suggest that the labeled-line design is partially at work in the Drosophila olfactory system.
    1. Cell Biology
    2. Neuroscience

    Microtubules originate asymmetrically at the somatic golgi and are guided via Kinesin2 to maintain polarity within neurons

    Amrita Mukherjee, Paul S Brooks ... Paul T Conduit
    The somatic Golgi acts as an asymmetric MTOC within Drosophila neurons, and this, together with the action Kinesin-2, helps maintain minus-end-out microtubule polarity with proximal dendrites.
    1. Neuroscience

    Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves

    Miriam Schwalm, Florian Schmid ... Albrecht Stroh
    Locally recorded calcium events related to slow wave activity show a global cortical fMRI BOLD correlate, establishing a direct relation between a basic neurophysiological signal and the macroscopic perspective of pre-clinical fMRI.
    1. Epidemiology and Global Health
    2. Medicine

    Conjunction of factors triggering waves of seasonal influenza

    Ishanu Chattopadhyay, Emre Kiciman ... Andrey Rzhetsky
    Three complementary computational approaches reveal a set of putative causes of initiation of pan-USA waves of influenza.
    1. Chromosomes and Gene Expression

    High levels of histones promote whole-genome-duplications and trigger a Swe1WEE1-dependent phosphorylation of Cdc28CDK1

    Douglas Maya Miles, Xenia Peñate ... Vincent Geli
    Ploidy is stably maintained in Saccharomyces cerevisae by a tight coordination between histone levels and cell cycle events.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Dynamic metastable long-living droplets formed by sticker-spacer proteins

    Srivastav Ranganathan, Eugene I Shakhnovich
    Multi-scale simulations reveal a potential, ATP-independent mechanism resulting in the formation of the long-living multi-droplet state by multi-valent, spacer-sticker proteins.
    1. Cell Biology

    Crumbs is an essential regulator of cytoskeletal dynamics and cell-cell adhesion during dorsal closure in Drosophila

    David Flores-Benitez, Elisabeth Knust
    The evolutionarily conserved polarity protein Crumbs links the regulation of cytoskeleton dynamics and cell-cell adhesion with epithelial morphogenesis.

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