Direct measurements of retinoic acid using fluorescence lifetime imaging reveal a new role for cellular retinoic acid binding proteins in noise attenuation that is critical to sharpen hindbrain rhombomere boundaries.
Noisy circadian clocks in Anabaena, coupled by cell-cell communication, display high spatio-temporal coherence and can be robustly described by incorporating demographic noise in a theoretical model of coupled clock arrays.
Proper development depends on establishing precise gene expression patterns in spite of the inherent noise in transcription, shadow enhancers buffer this noise by binding distinct input transcription factors.
Time-lapse recording and theoretical analysis of individual cells isolated from the zebrafish segmentation clock reveal that they behave as self-sustained, autonomous oscillators with distinctive noisy dynamics.
The maturation of multi-potent immature cells in the larval eye in Drosophila is regulated by a transcription factor that displays unexpected heterogeneous dynamics during the cells’ transitions towards differentiated states.