In-lab evolution of synthetic promoters has revealed a novel general mechanism for de novo evolution of gene regulation, and highlights the crucial role of expression noise in this process.
The impact of changing gene expression noise on fitness reveals beneficial or deleterious effects in a stable environment depending how close the average expression level is to the fitness optimum.
Direct measurements of retinoic acid using fluorescence lifetime imaging reveal a new role for cellular retinoic acid binding proteins in noise attenuation that is critical to sharpen hindbrain rhombomere boundaries.
Noisy circadian clocks in Anabaena, coupled by cell-cell communication, display high spatio-temporal coherence and can be robustly described by incorporating demographic noise in a theoretical model of coupled clock arrays.
Proper development depends on establishing precise gene expression patterns in spite of the inherent noise in transcription, shadow enhancers buffer this noise by binding distinct input transcription factors.
Time-lapse recording and theoretical analysis of individual cells isolated from the zebrafish segmentation clock reveal that they behave as self-sustained, autonomous oscillators with distinctive noisy dynamics.
Noise in a signaling network comprising thousands of molecules shapes diversity across cell populations and generates giant temporal fluctuations at the single-cell level.
The maturation of multi-potent immature cells in the larval eye in Drosophila is regulated by a transcription factor that displays unexpected heterogeneous dynamics during the cells’ transitions towards differentiated states.
