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    1. Developmental Biology

    Metabolic control of cellular immune-competency by odors in Drosophila

    Sukanya Madhwal, Mingyu Shin ... Tina Mukherjee
    Impact of odor experience on myeloid metabolism and immunity.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Assembly and positioning of actomyosin rings by contractility and planar cell polarity

    Ivonne M Sehring, Pierre Recho ... Di Jiang
    Contractility wins over the polarity pathway in a tug-of-war to position a cytokinesis-like actomyosin ring at the equator of notochord cells.
    1. Developmental Biology
    2. Immunology and Inflammation

    Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

    Jennifer C Regan, Mobina Khericha ... Linda Partridge
    In the fruit fly Drosophila melanogaster, stem cell activity ages female guts but not male guts; furthermore, males with feminized guts develop pathologies but gain an increase in lifespan through dietary restriction.
    1. Neuroscience

    Monosynaptic premotor circuit tracing reveals neural substrates for oro-motor coordination

    Edward Stanek IV, Steven Cheng ... Fan Wang
    Retrograde tracing of the neural circuits that control movement of the jaw and tongue reveals how shared premotor neurons help to ensure coordinated muscle activity.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Guanylate binding proteins directly attack Toxoplasma gondii via supramolecular complexes

    Elisabeth Kravets, Daniel Degrandi ... Klaus Pfeffer
    Cellular immunity against Toxoplasma parasites is orchestrated by GBP complexes attacking the parasite membrane.
    1. Medicine

    Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice

    Qi Sun, Gehua Zhen ... Xu Cao
    Parathyroid hormone attenuates osteoarthritis pain and joint degeneration by modification of subchondral bone remodeling and could be a potential disease-modifying therapy for osteoarthritis.
    1. Plant Biology

    Altered N-glycan composition impacts flagella-mediated adhesion in Chlamydomonas reinhardtii

    Nannan Xu, Anne Oltmanns ... Michael Hippler
    Adhesion force measurements reveal that proper N-glycosylation of flagellar membrane proteins is crucial for adhering C. reinhardtii cells onto surfaces.
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    Large, long range tensile forces drive convergence during Xenopus blastopore closure and body axis elongation

    David R Shook, Eric M Kasprowicz ... Raymond Keller
    Blastopore closure in Xenopus is driven by two morphogenic mechanisms that have strongly context dependent effects on tissue movement and that generate tensile force across tissues: convergent extension, as expected, and, unexpectedly, convergent thickening.
    1. Microbiology and Infectious Disease

    Targeting host deoxycytidine kinase mitigates Staphylococcus aureus abscess formation

    Volker Winstel, Evan R Abt ... Caius G Radu
    Host-directed therapy neutralizes a refined immuno-evasive maneuver of pathogenic staphylococci.
    1. Biochemistry and Chemical Biology

    Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility

    Dao-Lai Zhang, Yu-Jing Sun ... Jin-Peng Sun
    ADGRG2, an orphan GPCR, when coupled to CFTR via a regional Gq signaling on the apical membrane, acts to regulate efferent duct fluid reabsorption making it essential for male fertility.