5,583 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses

    Olga A Maximova et al.
    Virus infection of the central nervous system disrupts the homeostasis of the immune-neural-synaptic axis via induction of pleiotropic genes with an unintended off-target negative impact on the neurotransmission.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    HSV-1 single-cell analysis reveals the activation of anti-viral and developmental programs in distinct sub-populations

    Nir Drayman et al.
    Single-cell analyses of cells infected by Herpes Simplex Virus 1 revealed extreme heterogeneity among infected cells, including the robust activation of developmental gene programs in highly infected cells.
    1. Immunology and Inflammation

    Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection

    Ana-Carolina Oliveira et al.
    Development of a robust Th1 response to infection against an intracellular parasite requires T-cell intrinsic MyD88 signaling, mostly through the upstream IL-18 receptor, for the induction of genes involved in proliferation, cytokine production and migration.
    1. Cell Biology
    2. Immunology and Inflammation

    Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells

    Laura Marroqui et al.
    Pancreatic α and β cells have different cell autonomous signatures; this explains why α but not β cells can clear infections by potentially diabetogenic viruses.
    1. Genetics and Genomics

    One-step efficient generation of dual-function conditional knockout and geno-tagging alleles in zebrafish

    Wenyuan Li et al.
    Conditional gene knockout in combination with fluorescent labeling of different alleles can be achieved with high efficiency in zebrafish through NHEJ-mediated targeted insertion using a CRISPR/Cas system.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A large genomic insertion containing a duplicated follistatin gene is linked to the pea aphid male wing dimorphism

    Binshuang Li et al.
    The application of long-read sequencing to the pea aphid wing dimorphism system reveals genomic structural divergence as a genetic mechanism of adaptation.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Targeted, homology-driven gene insertion in stem cells by ZFN-loaded ‘all-in-one’ lentiviral vectors

    Yujia Cai et al.
    Building on previous work (Cai et al., 2014), HIV-derived lentiviral vectors are harnessed to insert user-defined genes into a safe locus in the genome of human stem cells.
    1. Chromosomes and Gene Expression

    A gene-specific T2A-GAL4 library for Drosophila

    Pei-Tseng Lee et al.
    A library of a thousand gene-specific intronic GAL4 insertions was generated, which caused a severe loss of function, permitted the assessing of gene expression, allowed the rescue of mutated gene with UAS-cDNA constructs, and provided a tool for the reversion of mutant phenotypes in specific cells or tissues.
    1. Microbiology and Infectious Disease

    Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity

    Patpicha Arunsan et al.
    Gene knockout of liver fluke granulin by CRISPR/Cas9 attenuates the virulence of infection with a carcinogenic liver fluke.
    1. Evolutionary Biology

    Constitutive activation of cellular immunity underlies the evolution of resistance to infection in Drosophila

    Alexandre B Leitão et al.
    Single-cell transcriptomics of immune cells demonstrates that populations evolve inducible defences when infection rates are low and constitutive defences when infection is common.

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