4,408 results found
    1. Genetics and Genomics

    Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy

    Sujatha Jagannathan et al.
    The myopathic transcription factor DUX4 induces discordant dysregulation of transcript and protein levels, demonstrating a key role for post-transcriptional gene regulation in facioscapulohumeral muscular dystrophy.
    1. Genetics and Genomics
    2. Neuroscience

    Increased processing of SINE B2 ncRNAs unveils a novel type of transcriptome deregulation in amyloid beta neuropathology

    Yubo Cheng et al.
    SINE RNAs are implicated in amyloid beta molecular pathology in hippocampus.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Morphological and genomic shifts in mole-rat ‘queens’ increase fecundity but reduce skeletal integrity

    Rachel A Johnston et al.
    In cooperatively breeding Damaraland mole-rats, transitioning to 'queen' results in extensive gene regulatory and morphological remodeling, but also costs to skeletal integrity that scale with reproductive investment.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The genetic factors of bilaterian evolution

    Peter Heger et al.
    Advanced orthology clustering of bilaterian and non-bilaterian sequences identifies 157 bilaterian-specific genes which are linked to key morphological features of this animal group.
    1. Cell Biology
    2. Neuroscience

    The cryptic gonadotropin-releasing hormone neuronal system of human basal ganglia

    Katalin Skrapits et al.
    Neuroanatomical studies reveal presence and cholinergic phenotype of 150,000-200,000 extrahypothalamic gonadotropin-releasing hormone neurons in human basal ganglia and basal forebrain, and RNA-sequencing detects gonadotropin-releasing hormone receptor-1 expression in cholinergic interneurons but not in spiny projection neurons of the human putamen.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Systematic bacterialization of yeast genes identifies a near-universally swappable pathway

    Aashiq H Kachroo et al.
    Despite billions of years of divergence, a majority of prokaryotic genes can functionally replace their essential eukaryotic counterparts, revealing broad preservation of ancestral functions and identifying heme biosynthesis as a near-universally swappable pathway.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

    Min Jung et al.
    A statistical method for summarizing single-cell gene expression data identifies normal and disease-specific transcriptional programs from an atlas of 57,600 cells.
    1. Evolutionary Biology

    Regulated aggregative multicellularity in a close unicellular relative of metazoa

    Arnau Sebé-Pedrós et al.
    The transition to the aggregative stage of Capsaspora owczarzaki, a close unicellular relative to Metazoa, is associated with significant upregulation of orthologs of genes that are important for multicellularity in metazoans.
    1. Evolutionary Biology

    A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees

    Michelle C Ward, Yoav Gilad
    Evolutionarily conserved hypoxic stress response genes are depleted for association with expression quantitative trait loci.
    1. Computational and Systems Biology
    2. Neuroscience

    Integrated systems analysis reveals conserved gene networks underlying response to spinal cord injury

    Jordan W Squair et al.
    Integrating decades of small-scale experiments with human gene expression data provides a systems-level view of the coordinated molecular processes triggered by spinal cord injury, and their relationship to recovery.

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