1,009 results found
    1. Structural Biology and Molecular Biophysics

    Distinct gating mechanisms revealed by the structures of a multi-ligand gated K+ channel

    Chunguang Kong, Weizhong Zeng ... Youxing Jiang
    Structural and functional studies of a potassium ion channel that is opened and closed by different ligands have revealed a novel gating mechanism.
    1. Neuroscience

    Hierarchical organization of context in the hippocampal episodic code

    Susumu Takahashi
    Neurons in the hippocampus modulate the rates at which they fire, and the locations in which they fire, so as to encode the information that is central to forming memories about personal experiences.
    1. Neuroscience

    Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice

    Wei Deng, Mark Mayford, Fred H Gage
    By using different groups of cells to represent distinct environments and events, the dentate gyrus of the hippocampus helps to keep memories of similar events separate.
    1. Neuroscience

    Skill learning strengthens cortical representations of motor sequences

    Tobias Wiestler, Jörn Diedrichsen
    Detailed analysis of fMRI data shows that sequences of movements are associated with individual patterns of neural activity that become more distinct with training.
    1. Microbiology and Infectious Disease

    Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse

    Jingtao Lilue, Urs Benedikt Müller ... Jonathan C Howard
    Mechanisms that enable wild mice to survive infection with strains of the Toxoplasma gondii parasite virulent enough to kill laboratory mice offer an explanation for how these parasites have been able to persist in the mouse population.
    1. Neuroscience

    Decoding neural responses to temporal cues for sound localization

    Dan FM Goodman, Victor Benichoux, Romain Brette
    Computer simulations of interaural time difference decoders show that heterogeneous tuning of binaural neurons leads to accurate sound localization in natural environments.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Fitness benefits in fluoroquinolone-resistant Salmonella Typhi in the absence of antimicrobial pressure

    Stephen Baker, Pham Thanh Duy ... Maciej F Boni
    The major evolutionary routes to drug resistance in Salmonella Typhi are associated with fitness benefits, not fitness costs, implying that prudent antimicrobial use will have no effect as a public health intervention in controlling typhoid fever.
    1. Neuroscience

    Pro-social behavior in rats is modulated by social experience

    Inbal Ben-Ami Bartal, David A Rodgers ... Peggy Mason
    Rats show socially selective helping behavior based on familiarity with the type of rat, but not necessarily the individual rat.
    1. Cell Biology
    2. Developmental Biology

    Plasticity of both planar cell polarity and cell identity during the development of Drosophila

    Pedro Saavedra, Jean-Paul Vincent ... José Casal
    In the Drosophila larval epidermis both the cell identity and polarity of individual cells change as a result of cell rearrangements.
    1. Neuroscience

    Inferring eye position from populations of lateral intraparietal neurons

    Arnulf BA Graf, Richard A Andersen
    An area of visual-motor cortex called the lateral intraparietal area encodes eye position signals that support visually-guided behaviors and image stabilization.

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