2,208 results found
    1. Genetics and Genomics

    The genetic basis for ecological adaptation of the Atlantic herring revealed by genome sequencing

    Alvaro Martinez Barrio, Sangeet Lamichhaney ... Leif Andersson
    Whole genome sequencing of 19 populations of Atlantic and Baltic herring reveals hundreds of individual loci underlying adaptation to a low salinity niche or timing of reproduction.
    1. Genetics and Genomics
    2. Plant Biology

    DNA methylation in Arabidopsis has a genetic basis and shows evidence of local adaptation

    Manu J Dubin, Pei Zhang ... Magnus Nordborg
    The adaptation of Arabidopsis plants to the local environment is linked to DNA methylation.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    History-dependent physiological adaptation to lethal genetic modification under antibiotic exposure

    Yuta Koganezawa, Miki Umetani ... Yuichi Wakamoto
    Single-cell time-lapse imaging and optogenetical gene recombination system uncovered that bacteria cells can overcome a deleterious genetic change of antibiotic resistance gene deletion depending on their environmental histories.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Drought adaptation in Arabidopsis thaliana by extensive genetic loss-of-function

    J Grey Monroe, Tyler Powell ... John K McKay
    Gene knockouts provide valuable genetic fuel for climate adaptation in nature.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Polygenic adaptation from standing genetic variation allows rapid ecotype formation

    Nico Fuhrmann, Celine Prakash, Tobias S Kaiser
    Baltic and Arctic ecotypes of the marine midge Clunio emerged from a recent adaptive radiation, which is based on standing genetic variation at many loci involved in time-keeping and nervous system development.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Niche-specific genome degradation and convergent evolution shaping Staphylococcus aureus adaptation during severe infections

    Stefano G Giulieri, Romain Guérillot ... Benjamin P Howden
    A large-scale analysis of Staphylococcus aureus within-host evolution based on a comprehensive catalogue of bacterial genetic variation reveals an excess of genome degradation signatures in infecting strains and new genetic loci of clinically relevant adaptation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Ecological adaptation in Atlantic herring is associated with large shifts in allele frequencies at hundreds of loci

    Fan Han, Minal Jamsandekar ... Leif Andersson
    Hundreds of loci underlying ecological adaptation to different environmental conditions show striking differences in allele frequencies between ecotypes of Atlantic herring.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Stable antibiotic resistance and rapid human adaptation in livestock-associated MRSA

    Marta Matuszewska, Gemma GR Murray ... Lucy A Weinert
    The dominant MRSA circulating in European livestock has stably maintained genes associated with resistance to antibiotic treatments over several decades and when it is transmitted to humans it can rapidly acquire genes that allow it to evade human immune responses.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Evolution of extreme resistance to ionizing radiation via genetic adaptation of DNA repair

    Rose T Byrne, Audrey J Klingele ... Michael M Cox
    Experiments on E. coli show that multiple mechanisms contribute to extreme resistance to ionizing radiation in bacteria, with mutations to three genes for DNA repair having a prominent role in one evolved population.
    1. Genetics and Genomics

    Genetic variation in adaptability and pleiotropy in budding yeast

    Elizabeth R Jerison, Sergey Kryazhimskiy ... Michael M Desai
    Substantial heritable genetic variation in adaptability and the pleiotropic consequences of adaptation exists in budding yeast, and can be explained by a combination of fitness and specific segregating alleles.

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