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    1. Evolutionary Biology

    Decreased recent adaptation at human mendelian disease genes as a possible consequence of interference between advantageous and deleterious variants

    Chenlu Di, Jesus Murga Moreno ... David Enard
    Harmful genetic variants at mendelian disease genes slow down adaptation, by interfering with the spread of adaptive variants in a population.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection

    Magdalena Steinrueck, Călin C Guet
    Experimental evolution reveals how adaptation by increased expression of a gene depends on a combination of simple genetic properties of the gene's neighbors on the DNA.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Rapid sex-specific adaptation to high temperature in Drosophila

    Sheng-Kai Hsu, Ana Marija Jakšić ... Christian Schlötterer
    Within 100 generations after an environmental shift in an evolution experiment, rapid sex-specific adaptation occurred, which is potentially facilitated by selection on standing variation in sex-specific genetic architecture.
    1. Genetics and Genomics

    Genetic variation in offspring indirectly influences the quality of maternal behaviour in mice

    David George Ashbrook, Beatrice Gini, Reinmar Hager
    A cross-fostered population of mice reveals loci on offspring chromosomes 5 and 7 that modify the behaviour of their mothers, along with evidence of coadaptation between offspring and parental traits.
    1. Evolutionary Biology

    Sex-biased regulatory changes in the placenta of native highlanders contribute to adaptive fetal development

    Tian Yue, Yongbo Guo ... Bing Su
    Comparative transcriptome analyses of human placenta reveal regulatory divergence between native highlanders and lowland immigrants living at high altitude, and a sex-biased pattern of genetic adaptation.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The landscape of transcriptional and translational changes over 22 years of bacterial adaptation

    John S Favate, Shun Liang ... Premal Shah
    Parallel changes in organismal evolution can be observed even with disparate genomic changes due to similarity in functional outcomes, such as changes in molecular phenotypes like gene expression patterns.
    1. Genetics and Genomics

    Genome-wide association study in quinoa reveals selection pattern typical for crops with a short breeding history

    Dilan SR Patiranage, Elodie Rey ... Christian Jung
    A new insight into quinoa diversity enables sequence-based breeding and functional genomics.
    1. Genetics and Genomics

    Data-driven, participatory characterization of farmer varieties discloses teff breeding potential under current and future climates

    Aemiro Bezabih Woldeyohannes, Sessen Daniel Iohannes ... Matteo Dell'Acqua
    A genomic, climatic, agronomic, and participatory characterization of teff agrobiodiversity shows opportunities and challenges of teff improvement in the face of climate change.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Gene expression plasticity followed by genetic change during colonization in a high-elevation environment

    Huishang She, Yan Hao ... Yanhua Qu
    An integrative approach allows investigations of the relationship between an initial plasticity and the subsequent adaptive evolution during rapid adaptive modification of complex systems in the wild.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Archaic introgression contributed to shape the adaptive modulation of angiogenesis and cardiovascular traits in human high-altitude populations from the Himalayas

    Giulia Ferraretti, Paolo Abondio ... Marco Sazzini
    A combination of composite-likelihood and gene network-based methods to investigate the impact of Denisovan introgression on the evolution of complex (i.e., polygenic) adaptive traits in high-altitude populations of Tibetan/Sherpa ancestry.