3,380 results found
    1. Cancer Biology
    2. Genetics and Genomics

    Targets and genomic constraints of ectopic Dnmt3b expression

    Yingying Zhang et al.
    Ectopic expression of Dnmt3b leads to wide-spread CpG island hypermethylation that is largely defined by chromatin state and has some distinct features when compared to the cancer methylome.
    1. Evolutionary Biology

    Subterranean mammals show convergent regression in ocular genes and enhancers, along with adaptation to tunneling

    Raghavendran Partha et al.
    Repeated evolution of eye regression in subterranean mammals helps identify genes and regulatory elements involved in visual perception and development of the eye, and predicts candidate sequences with a potential role in ocular disorders.
    1. Evolutionary Biology

    Experimental evolution reveals hidden diversity in evolutionary pathways

    Peter A Lind et al.
    Genetic architecture governs the evolvability of adaptive paths providing a framework for evolutionary forecasting.
    1. Computational and Systems Biology
    2. Ecology

    Trade-off shapes diversity in eco-evolutionary dynamics

    Farnoush Farahpour et al.
    In a minimalistic, generic model of competitive communities in which evolution is constrained by life-history trade-offs, stable biodiversity emerges with species adapted to different functional niches.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Epidemiology: Promiscuous bacteria have staying power

    Ruth C Massey, Daniel J Wilson
    Being able to take up DNA from their environment might allow pneumococcal bacteria to colonize the human nose and throat for longer periods of time.
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    1. Cell Biology
    2. Microbiology and Infectious Disease

    Point of View: Is cell size a spandrel?

    Ariel Amir
    Analysis of experiments on bacteria suggests that the dependence of cell size on growth rate is not an adaptation but a causal consequence of a regulatory mechanism that controls DNA replication.
    1. Neuroscience

    Locomotion: Building behaviors, one layer at a time

    Claire Wyart, Vatsala Thirumalai
    New interneurons are added in the hindbrain to support more complex movements as young zebrafish get older.
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    1. Computational and Systems Biology

    Point of View: Data science for the scientific life cycle

    Daphne Ezer, Kirstie Whitaker
    Each stage of the scientific life cycle stands to benefit from the introduction of data science techniques.
    1. Structural Biology and Molecular Biophysics

    Ion Channels: Solving a specificity mystery

    Sanduo Zheng, Andrew C Kruse
    Differences in the kinetics of G protein activation can explain why only some receptors can activate potassium ion channels called GIRKs.
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    1. Developmental Biology

    Signaling: Enzymatic insights into an inherited genetic disorder

    Liping Zhang, Kelly G Ten Hagen
    Mutations in an enzyme involved in protein degradation affect a signaling pathway that stimulates the development of the digestive tract.
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