Margaret L Antonio, Clemens L Weiß ... Jonathan K Pritchard
Reconstructing human mobility patterns using historical period genomes illustrates how the Roman Empire’s military and economic activities catalyzed an era of transient movement against the backdrop of generations-long prehistoric migrations.
Yuttapong Thawornwattana, Fernando Seixas ... James Mallet
The full-likelihood multispecies coalescent approach is useful for studying species groups with high rates of introgression from whole-genome sequence data.
Stefan Strütt, Thibaut Sellinger ... Stefan Laurent
Transitions from outcrossing to selfing, a major shift in mating systems, create a specific signature in intra-specific genetic polymorphisms, which can be used to infer the demographic history of populations and acquire valuable insights about the evolution of recombination rates.
M Elise Lauterbur, Maria Izabel A Cavassim ... Ilan Gronau
Stdpopsim, a framework for generating realistic chromosome-scale simulations, is expanded to facilitate simulations for non-model species, resulting in insights into how such simulations should be designed.
A new framework for mutation spectrum analysis reveals multiple independent changes in the germline mutation patterns of human populations, which cannot be explained by shifts in average ages at reproduction.
Selective sweepstakes from pervasive positive selection, rather than demographic changes or random sweepstakes reproduction, is the primary determinant of reproductive skew and genetic diversity in the highly prolific Atlantic cod.
Julia M Kreiner, George Sandler ... Stephen I Wright
The spread of herbicide resistance in one of the most problematic weeds in North America occurs through both recent, repeated mutational origins and gene flow across an international network of agricultural fields.
Methylated CpG sites are saturated for T mutations in a sample of 390K human exomes, providing a test case for inferences about fitness effects in human genes, and insight into the interpretation of mutations as pathogenic using reference datasets.
In addition to its academic merits, characterizing the genetic determinants of male (in)fertility and identifying clinically actionable genetic variants can lead to improved diagnosis or even treatment of such conditions.
