Catalin Mitelut, Yongxu Zhang ... Timothy H Murphy
Mouse self-initiated behaviors can be identified seconds prior to action and have similar neuro-dynamical structure to neural dynamics underlying human voluntary actions supporting the use of mouse models in self-initiated and volitional action research.
Single-cell tracking and cell-fate simulation suggest that low levels of p53 suppress aneuploid cell formation in unstressed cells and also reveal the dual fate of cells lacking p53 in the presence of p53-proficient cells.
The endosomal apparatus of African trypanosomes consists a continuous membrane system with functional subdomains rather than distinct compartments for early, late, and recycling endosomes.
Felix F Fuchsberger, Dongyoon Kim ... Christoph Rademacher
The information stored in glycans is interpreted and read by cell surface-exposed lectin receptors, and with information theory, the formal framework is set for how to analyze such complex single-cell data.
Hajnalka L Pálinkás, Angéla Békési ... Beáta G Vértessy
Human genomic DNA contains uracil in the late replicating, constitutive heterochromatic regions, while treatment with drugs perturbing thymidylate biosynthesis shifts the uracil distribution pattern towards the euchromatin in UNG-inhibited cells.
The first postnatal week ends with the development of perisomatic innervation and with an abrupt switch in the representation of self-motion in the region CA1 of the mouse hippocampus.
The structural integrity of the right superior longitudinal fasciculus was identified as a neuroimaging predictor of chronic back pain, with potential for clinical translation.
Julio D Perez, Nimrod D Rubinstein ... Catherine Dulac
A subset of genes in the mouse brain show dynamically regulated and unequal expression of maternally and paternally derived variants, with implications for brain development and function.
Luca Casiraghi, Francesco Mambretti ... Tommaso Bellini
A variant of SELEX introduced here to induce abiotic evolution in a molecular system enables to observe and study speciation, the nature of fitness, and the interplay between use of resources and interactions between individuals.