2,094 results found
    1. Computational and Systems Biology
    2. Neuroscience

    Mesoscale cortex-wide neural dynamics predict self-initiated actions in mice several seconds prior to movement

    Catalin Mitelut, Yongxu Zhang ... Timothy H Murphy
    Mouse self-initiated behaviors can be identified seconds prior to action and have similar neuro-dynamical structure to neural dynamics underlying human voluntary actions supporting the use of mouse models in self-initiated and volitional action research.
    1. Computational and Systems Biology

    Empirical single-cell tracking and cell-fate simulation reveal dual roles of p53 in tumor suppression

    Ann Rancourt, Sachiko Sato, Masahiko S Satoh
    Single-cell tracking and cell-fate simulation suggest that low levels of p53 suppress aneuploid cell formation in unstressed cells and also reveal the dual fate of cells lacking p53 in the presence of p53-proficient cells.
    1. Cell Biology

    Continuous endosomes form functional subdomains and orchestrate rapid membrane trafficking in trypanosomes

    Fabian Link, Alyssa Borges ... Markus Engstler
    The endosomal apparatus of African trypanosomes consists a continuous membrane system with functional subdomains rather than distinct compartments for early, late, and recycling endosomes.
    1. Cell Biology
    2. Computational and Systems Biology

    Information transfer in mammalian glycan-based communication

    Felix F Fuchsberger, Dongyoon Kim ... Christoph Rademacher
    The information stored in glycans is interpreted and read by cell surface-exposed lectin receptors, and with information theory, the formal framework is set for how to analyze such complex single-cell data.
    1. Neuroscience

    Spike frequency adaptation supports network computations on temporally dispersed information

    Darjan Salaj, Anand Subramoney ... Wolfgang Maass
    Spike frequency adaptation provides spiking neural networks with long short-term memory.
    1. Chromosomes and Gene Expression

    Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments

    Hajnalka L Pálinkás, Angéla Békési ... Beáta G Vértessy
    Human genomic DNA contains uracil in the late replicating, constitutive heterochromatic regions, while treatment with drugs perturbing thymidylate biosynthesis shifts the uracil distribution pattern towards the euchromatin in UNG-inhibited cells.
    1. Neuroscience

    The rapid developmental rise of somatic inhibition disengages hippocampal dynamics from self-motion

    Robin F Dard, Erwan Leprince ... Michel A Picardo
    The first postnatal week ends with the development of perisomatic innervation and with an abrupt switch in the representation of self-motion in the region CA1 of the mouse hippocampus.
    1. Neuroscience

    A multisite validation of brain white matter pathways of resilience to chronic back pain

    Mina Mišić, Noah Lee ... Herta Flor
    The structural integrity of the right superior longitudinal fasciculus was identified as a neuroimaging predictor of chronic back pain, with potential for clinical translation.
    1. Neuroscience

    Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain

    Julio D Perez, Nimrod D Rubinstein ... Catherine Dulac
    A subset of genes in the mouse brain show dynamically regulated and unequal expression of maternally and paternally derived variants, with implications for brain development and function.
    1. Ecology

    Synthetic eco-evolutionary dynamics in simple molecular environment

    Luca Casiraghi, Francesco Mambretti ... Tommaso Bellini
    A variant of SELEX introduced here to induce abiotic evolution in a molecular system enables to observe and study speciation, the nature of fitness, and the interplay between use of resources and interactions between individuals.

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