2,867 results found
    1. Developmental Biology and Stem Cells

    Positional information specifies the site of organ regeneration and not tissue maintenance in planarians

    Eric M Hill, Christian P Petersen
    Homeostatic tissue maintenance can occur at locations distinct from the target sites of organ regeneration planarians.
    1. Epidemiology and Global Health

    Conjunction of factors triggering waves of seasonal influenza

    Ishanu Chattopadhyay et al.
    Three complementary computational approaches reveal a set of putative causes of initiation of pan-USA waves of influenza.
    1. Neuroscience

    Salient experiences are represented by unique transcriptional signatures in the mouse brain

    Diptendu Mukherjee et al.
    Inducible transcription in the brain encodes detailed aspects of recent experience.
    1. Cancer Biology
    2. Cell Biology

    Laminin signals initiate the reciprocal loop that informs breast-specific gene expression and homeostasis by activating NO, p53 and microRNAs

    Saori Furuta et al.
    Endogenous laminins are necessary to build a functional acinus via generating NO, activating p53, HOXD10 and other positive players, but tumor cells neither make laminin nor generate NO, unless they are reverted to an organized structure.
    1. Developmental Biology and Stem Cells

    A switch in transcription and cell fate governs the onset of an epigenetically-deregulated tumor in Drosophila

    Joana Torres et al.
    A previously unknown oncogenic feature of an embryonic transcription factor was uncovered from transcriptomic analysis of tumors that lack functional Polycomb silencing.
    1. Cell Biology

    SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation

    Mohsen Sarikhani et al.
    Mass spectroscopy, molecular modeling and/or molecular dynamics simulations reveal how acetylation regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation.
    1. Computational and Systems Biology
    2. Neuroscience

    Automated analysis of long-term grooming behavior in Drosophila using a k-nearest neighbors classifier

    Bing Qiao et al.
    Drosophila grooming is driven by two internal programs.
    1. Cancer Biology
    2. Genes and Chromosomes

    Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

    Simeon U Springer et al.
    The creation of a non-invasive assay for detecting urothelial cancer could have a profound impact on how we find and treat the disease.
    1. Neuroscience

    Neurogliaform cortical interneurons derive from cells in the preoptic area

    Mathieu Niquille et al.
    In vivo genetic lineage-tracing reveals the developmental trajectory of neurogliaform cells, the main effectors of a powerful inhibitory motif in the neocortex.
    1. Neuroscience

    Auditory experience controls the maturation of song discrimination and sexual response in Drosophila

    Xiaodong Li et al.
    Auditory experience of a species-specific courtship song in developing Drosophila tunes adult song perception and resultant sexual behavior more selective.

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