4,736 results found
    1. Structural Biology and Molecular Biophysics

    Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis

    Trayambak Pathak et al.
    Colorectal tumors down-regulate the mitochondrial Na+/Ca2+/Li+ exchanger (NCLX) to alter mitochondrial Ca2+ signaling and initiate transcriptional and metabolic reprogramming that drives tumor chemo-resistance and metastasis.
    1. Computational and Systems Biology
    2. Developmental Biology

    Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

    Sumeda Nandadasa et al.
    Morphologic, molecular, biomechanical and computational analyses show that the specialized extracellular matrix architecture of the umbilical artery contributes to its rapid closure at birth and regulates smooth muscle cell differentiation.
    1. Computational and Systems Biology
    2. Neuroscience

    Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations

    Adam C Lu et al.
    A multi-scale integration of experimental and computational approaches shows how a non-linear dependence of T-type calcium channel gating on GABAB receptor activity regulates thalamic network oscillations.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors

    Laura Crowley et al.
    Single-cell analyses identify distinct epithelial populations that are conserved between the adult mouse and human prostate, including populations with properties of multipotent progenitors in organoid formation and tissue reconstitution assays.
    1. Cancer Biology
    2. Cell Biology

    IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation

    Li Pan et al.
    Unbiased analyses highlight context-specific crosstalk between Notch, DNA damage response genes, and PP2A, and provide a roadmap for understanding how Notch induces squamous cell differentiation.
    1. Cell Biology

    Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit

    James Holder et al.
    Selective APC/C-mediated proteolysis of cyclin B drives progression through the metaphase-anaphase transition whilst wide-spread waves of dephosphorylation co-ordinate the subsequent events of mitotic exit.
    1. Neuroscience

    Ribosomal profiling during prion disease uncovers progressive translational derangement in glia but not in neurons

    Claudia Scheckel et al.
    Cell-type-specific ribosome profiling during prion disease progression identified minor translational changes in neurons as well as profound glia changes many of which are shared with other neurodegenerative diseases.
    1. Neuroscience

    Long ascending propriospinal neurons provide flexible, context-specific control of interlimb coordination

    Amanda M Pocratsky et al.
    Conditional silencing of long ascending propriospinal neurons disrupts interlimb coordination of the fore and hindlimb pairs, but in a highly context-specific manner.
    1. Medicine

    Performance of a deep learning based neural network in the selection of human blastocysts for implantation

    Charles L Bormann et al.
    A well-trained deep learning neural network can outperform and can potentially assist expertly trained embryologists in selecting embryos based on their implantation potential, even amongst high-quality euploid blastocyst embryos.
    1. Computational and Systems Biology
    2. Neuroscience

    New insights on the modeling of the molecular mechanisms underlying neural maps alignment in the midbrain

    Elise Laura Savier et al.
    A dominant sensory map provides positional information through correlated activity and transposed molecular cues to guide secondary sensory projections for alignment and organization.

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