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Analysis of 458 Kalinago provides new insights into the population's genetic structure, the contribution of Native American ancestry to skin pigmentation, and the identification of a coding variant in OCA2 with an estimated –8 melanin units effect size.

Epigenetic regulations in the smoking- and blood pressure-related pathways to the future risk of coronary heart disease may reveal novel pathways or therapeutic targets.

Genetic variation can impact multiple levels of gene regulation and disease through alternative polyadenylation.

3D serial electron microscopy reveals that individual dopamine axons in the nucleus accumbens contain different varicosity types based on their vesicle contents, rarely make synapses, and undergo major structural plasticity in response to cocaine.

Genetic effects on body weight in mice are highly heterogeneous, dynamic, and nonlinear with respect to genomic background, age, and diet.

The location of neurons responsible for increasing the breathing rate upon detecting elevated levels of CO₂ in the blood has been pinpointed to the retrotrapezoid nucleus in the brainstem.

Computational analysis reveals that additive summary statistics from genome-wide association studies can provide evidence of non-additive heritability in complex traits.

Inhibition of RyR2 hyperactivity with dantrolene not only prevents VT/VF and SCD but also heart failure by mitigating calcium dysfunction in pressure-overloaded hearts.

Variation in the rate of mixed infections by malaria parasites and the relatedness structure among infecting strains reveals diversity in local epidemiological processes.

Rendering compound vision at high speed with high precision, enabling rapid, data-driven exploration of the compound eye design space.