4,271 results found
    1. Ecology
    2. Evolutionary Biology

    The evolution of non-reproductive workers in insect colonies with haplodiploid genetics

    Jason W Olejarz et al.
    A mathematical model predicts the precise conditions for natural selection to favor the evolution of non-reproductive workers in insect colonies with haplodiploid genetics.
    1. Microbiology and Infectious Disease

    Changes in the genetic requirements for microbial interactions with increasing community complexity

    Manon Morin et al.
    Analysis of the global genetic requirements and gene expression changes in E. coli in the presence of a simple microbiome revealed pairwise and higher-order interactions, and underlying molecular mechanisms.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Dissection of zebrafish shha function using site-specific targeting with a Cre-dependent genetic switch

    Kotaro Sugimoto et al.
    A versatile invertible gene trap vector is generated and inserted into a defined genomic locus in zebrafish via homologous recombination, demonstrating an efficient genetic approach to performing conditional knockout analysis.
    1. Genetics and Genomics

    Passive and active DNA methylation and the interplay with genetic variation in gene regulation

    Maria Gutierrez-Arcelus et al.
    Detailed analysis of umbilical cord cells shows that the associations between DNA methylation, gene expression and genetic variation are complex and context-dependent.
    1. Neuroscience

    Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains

    Diane M Bushman et al.
    Somatically derived genomic mosaicism in the form of increased DNA content and APP copy number in single neurons plausibly has a function in sporadic Alzheimer’s disease and points to functions for single-neuron gene copy number changes.
    1. Chromosomes and Gene Expression

    Paternal Effects: Like father, like son

    Claude Becker
    Exposing male mice to nicotine or cocaine enables their male offspring to cope with high doses of either, which suggests that such paternal effects are generic, rather than being a response to a specific type of stress.
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    1. Ecology
    2. Evolutionary Biology

    The Natural History of Model Organisms: Advancing biology through a deeper understanding of zebrafish ecology and evolution

    David M Parichy
    The zebrafish is a premier model organism for biomedical research, with a rich array of tools and genomic resources, and combining these with a fuller appreciation of wild zebrafish ecology could greatly extend its utility in biological research.
    1. Cancer Biology
    2. Computational and Systems Biology

    Synthesizing artificial devices that redirect cellular information at will

    Yuchen Liu et al.
    A novel RNA-based trans-regulatory system that control gene expression in mammalian cells has been developed and they can be coupled to endogenous signals.

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