Salsa6f is a novel, ratiometric genetically encoded Ca²⁺ indicator that combines the power of ratiometric chemical Ca²⁺ indicators with the ability, when expressed transgenically, to image cellular Ca²⁺ signals amid complex tissue environments in vivo.

Orai1 channels activate intermittently in motile T cells, generating calcium transients, detected by a novel genetically encoded indicator and inducing pauses that favor antigen scanning.

Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.

Research into genomic imprinting has provided a foundation for the study of epigenetic mechanisms, especially during development, and has also shed light on a range of rare genetic disorders and common diseases.

Studies of the house mouse Mus musculus have provided important insights into mammalian biology, and efforts to study wild house mice and to create new inbred strains from wild populations have the potential to increase its usefulness as a model system.

The yeast Saccharomyces cerevisiae has informed our understanding of molecular biology and genetics for decades, and learning more about its natural history could fuel a new era of functional and evolutionary studies of this classic model organism.

We discuss the methods available to understand lncRNA function in vivo, and highlight important considerations that should be taken into account when designing such experiments.

Tumor-growth-factor-beta signaling helps cancer cells to evolve and become resistant to drugs by down-regulating accurate DNA repair.

A pain-relaying ion channel on a hypersensitive population of sensory neurons can instead elicit sensations of itch in both fish and mice when directly activated, providing a novel model of itch transduction.