The helical rod structure and dynamic spring-like properties of the type 1 pilus are evolutionarily fine-tuned for functioning in host-pathogen interactions during urinary tract infection and gut colonization.
Loss and gain-of-function investigation uncovers a regulatory network controlling human heart chamber specification in which the cardiac precursor gene ISL1 accelerates ventricular induction and antagonizes retinoic acid-driven atrial commitment.
Single-cell FRET measurements reveal large temporal activity fluctuations within this signaling pathway in Escherichia coli, caused by stochasticity of receptor methylation combined with allosteric interactions and slow rearrangements within receptor clusters.
Minimizing anti-proliferation signaling from DNA damage detection machinery is the tactic for the cells to drive proliferation under genotoxic environment, and the function is exerted by Polo-Like-Kinase1 that is frequently over-expressed in cancer cells.
Locally recorded calcium events related to slow wave activity show a global cortical fMRI BOLD correlate, establishing a direct relation between a basic neurophysiological signal and the macroscopic perspective of pre-clinical fMRI.