327 results found
    1. Neuroscience

    Fast two-photon imaging of subcellular voltage dynamics in neuronal tissue with genetically encoded indicators

    Simon Chamberland et al.
    The combination of a new genetically encoded voltage indicator and fast two-photon imaging methods enables detection of rapid neural electrical activity in organotypic slice cultures and in living flies.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Single-molecule fluorimetry and gating currents inspire an improved optical voltage indicator

    Jeremy S Treger et al.
    ArcLight, a popular optogenetic reporter of voltage, is studied at both single-molecule and macroscopic levels, which leads to new mechanistic understanding and to the rational design of a faster reporter.
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Optical estimation of absolute membrane potential using fluorescence lifetime imaging

    Julia R Lazzari-Dean et al.
    Fluorescence lifetime imaging microscopy, paired with fluorescent, voltage-sensitive dyes, provides a method for measuring and quantifying membrane potentials of living cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation

    Lian He et al.
    A near-infrared light-stimulable optogenetic platform enables remote and wireless manipulation of calcium signaling and immune responses both in vitro and in vivo to achieve tailored function.
    1. Structural Biology and Molecular Biophysics

    TMEM266 is a functional voltage sensor regulated by extracellular Zn2+

    Ferenc Papp et al.
    Transmembrane protein 266 contains a functional S1-S4 voltage-sensing domain that is regulated by extracellular Zn2+ ions.
    1. Microbiology and Infectious Disease

    Membrane voltage dysregulation driven by metabolic dysfunction underlies bactericidal activity of aminoglycosides

    Giancarlo Noe Bruni, Joel M Kralj
    Aminoglycosides are a class of antibiotics that can kill Escherichia coli by building up internal voltage through disrupting the normal consumption of ATP.
    1. Neuroscience

    A resource for the Drosophila antennal lobe provided by the connectome of glomerulus VA1v

    Jane Anne Horne et al.
    FIB-SEM is used to identify comprehensively and reconstruct 192 neurons and their complete connectome for glomerulus VA1v of the Drosophila antennal lobe, in particular to reconstruct its local interneurons.
    1. Cell Biology

    Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity

    Joseph A Giovinazzo et al.
    Cytotoxicity associated with APOL1 renal-risk variants occurs through its plasma-membrane localization, where aberrant channel activity drives a sustained sodium and calcium influx leading to cell swelling and eventually cell death.
    1. Cell Biology

    ATP activation of peritubular cells drives testicular sperm transport

    David Fleck et al.
    Purinergic signaling controls mammalian sperm transport.
    1. Neuroscience

    Calcium imaging with genetically encoded indicators in behaving primates

    Eyal Seidemann et al.
    The link between the activity of large populations of cortical neurons and single neuron responses is examined in primates using a new optical-genetic method.

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