380 results found
    1. Cell Biology

    Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

    Thomas M Rawlings et al.
    The study of embryo-endometrial interactions in assembloid co-cultures identifies novel mechanisms of reproductive failure.
    1. Cell Biology
    2. Neuroscience

    TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis

    Zhong-Jiao Jiang et al.
    Electrophysiological and live-cell imaging analyses identify a presynaptic function of Ca2+ influx via transient receptor potential melastatin 7 (TRPM7) channels.
    1. Neuroscience

    The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges

    Pierre-Luc Rochon et al.
    A novel retinal ganglion cell requires a cell adhesion molecule to grow its dendrites, collect synaptic inputs, and become selective to edges placed in its receptive field.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

    Solène N Lefebvre et al.
    A pentameric channel-receptor was studied by combining allosteric mutations, electrophysiology, fluorescent reporters and normal mode analysis, to dissect the long-range allosteric couplings specifically involved in its pre-activation and activation.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Multiple introductions of multidrug-resistant typhoid associated with acute infection and asymptomatic carriage, Kenya

    Samuel Kariuki et al.
    Carriage of MDR S. Typhi H58 sublineages that also cause acute disease provides understanding of the transmission dynamics of typhoid fever and maintenance of local pathogen populations in Kenya children.
    1. Neuroscience

    Modeling spinal locomotor circuits for movements in developing zebrafish

    Yann Roussel et al.
    Computational models of spinal locomotor circuits in developing zebrafish reveal how new movements can emerge during development through the integration of new spinal neurons and new connections.
    1. Structural Biology and Molecular Biophysics

    The mechanism of MICU-dependent gating of the mitochondrial Ca2+uniporter

    Vivek Garg et al.
    A comprehensive functional analysis of mitochondrial Ca2+ uniporter (MCU) demonstrates that the auxiliary MICU subunits potentiate Ca2+ transport via MCU.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens

    Robert Coukos et al.
    HiLITR is a molecular reporter of protein localization that enables straightforward, large-scale, fluorescence-activated cell sorting-based discovery of genes that regulate complex cellular processes, such as mitochondrial and ER tail-anchored protein trafficking.
    1. Neuroscience

    Activity-dependent regulation of mitochondrial motility in developing cortical dendrites

    Catia AP Silva et al.
    Naturally occurring activity in the developing brain regulates mitochondrial motility such that mitochondria stop at active synapses, which is probably a fundamental process in brain wiring.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A precisely adjustable, variation-suppressed eukaryotic transcriptional controller to enable genetic discovery

    Asli Azizoglu et al.
    A new gene expression tool enables precise control of protein dosage over a large range and paves the way for new genetic discoveries.

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