6,317 results found
    1. Developmental Biology
    2. Evolutionary Biology

    Multicellularity: The evolution of gene regulation

    Veronica Hinman, Gregory Cary
    The gene regulation mechanisms necessary for the development of complex multicellular animals have been found in sponges.
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    1. Microbiology and Infectious Disease

    Research: A comprehensive and quantitative exploration of thousands of viral genomes

    Gita Mahmoudabadi, Rob Phillips
    A compendium of critical genomic numbers for viruses through the lenses of different viral classification systems.
    1. Developmental Biology
    2. Genetics and Genomics

    2018 Gairdner Awards: The discovery and importance of genomic imprinting

    Anne C Ferguson-Smith, Deborah Bourc'his
    Research into genomic imprinting has provided a foundation for the study of epigenetic mechanisms, especially during development, and has also shed light on a range of rare genetic disorders and common diseases.
    1. Human Biology and Medicine

    Point of View: How should the applications of genome editing be assessed and regulated?

    Robin Fears, Volker ter Meulen
    An EASAC working group on genome editing recommends that regulators should focus on specific applications of these new techniques rather than attempting to regulate genome editing itself as a new technology.
    1. Plant Biology

    Point of View: Europe’s first and last field trial of gene-edited plants?

    Jean-Denis Faure, Johnathan A Napier
    The reclassification of gene editing as "GM" will impact on European plant sciences, making it more difficult to validate new traits in field trials and drive forward innovation.
    1. Ecology
    2. Chromosomes and Gene Expression

    Emerging Technology: Concerning RNA-guided gene drives for the alteration of wild populations

    Kevin M Esvelt et al.
    Combining CRISPR/Cas9 genome editing with gene drives may enable scientists to reversibly edit the genomes of diverse wild populations, an advance that could help eliminate diseases, support sustainable agriculture, and control invasive species.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

    Jennifer Jung et al.
    An image-based multiplex autophagosome RNAi screen targeting all Rab GTPases as well as their GAPs and GEFs identifies the Rab GEF SMCR8 as multifaceted autophagy modulator, which regulates kinase activity and gene expression of ULK1.
    1. Developmental Biology
    2. Genetics and Genomics

    The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion

    Damian Kao et al.
    The first malacostracan genome sequence will establish the genetically tractable Parhyale hawaiensis as a model organism in this key animal group.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity

    Welkin H Pope et al.
    A continuum of genome relationships is discovered through comparative genomics of 627 sequenced mycobacteriophages isolated and characterized in an integrated research/education initiative.
    1. Genetics and Genomics

    RNA-programmed genome editing in human cells

    Martin Jinek et al.
    A bacterial protein can be programmed with short RNA molecules to stimulate genome editing at specific sites in human cells.

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