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    1. Cell Biology
    2. Developmental Biology

    Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation

    Leah C Biggs, Otto JM Mäkelä ... Marja L Mikkola
    The hair follicle dermal condensate is populated via migration, and the cells exhibit early changes in cell shape and cell cycle status; Fgf20 primes these cellular and molecular events.
    1. Neuroscience

    A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes

    Blaise Robert, Eyal Y Kimchi ... Daniel B Polley
    Activity levels in anterior and posterior cholinergic basal forebrain neurons are associated with distinct aspects of global brain state, sensory salience, reward expectation, and aversive reinforcement learning.
    1. Neuroscience

    An hourglass circuit motif transforms a motor program via subcellularly localized muscle calcium signaling and contraction

    Steven R Sando, Nikhil Bhatla ... H Robert Horvitz
    By driving the localized contraction of subcellular muscle regions, a single motor neuron reverses the flow of material in the Caenorhabditis elegans pharynx, a neuromuscular pump, converting feeding into spitting.
    1. Neuroscience

    Experimentally induced active and quiet sleep engage non-overlapping transcriptional programs in Drosophila

    Niki Anthoney, Lucy Tainton-Heap ... Bruno van Swinderen
    Different methods for inducing sleep in Drosophila flies may be promoting distinct sleep stages with different functions when brain activity and gene expression are compared.
    1. Evolutionary Biology

    Selection and the direction of phenotypic evolution

    François Mallard, Bruno Afonso, Henrique Teotónio
    Predicting multivariate phenotypic evolution.
    1. Neuroscience

    Drosulfakinin signaling encodes early-life memory for adaptive social plasticity

    Jiwon Jeong, Kujin Kwon ... Chunghun Lim
    Social clustering behaviors in Drosophila are closely tied to compensatory mechanisms for developmental traits and adaptive behavior plasticity, requiring early-life social experiences and the memory-encoding neuropeptide signaling pathway.
    1. Cell Biology
    2. Neuroscience

    Systematic functional analysis of rab GTPases reveals limits of neuronal robustness to environmental challenges in flies

    Friederike E Kohrs, Ilsa-Maria Daumann ... P Robin Hiesinger
    The first complete null mutant collection of all rab GTPase genes in a multicellular organism uncovers neuronal development and function sensitive to environmental challenges in Drosophila.
    1. Developmental Biology

    Emx2 regulates hair cell rearrangement but not positional identity within neuromasts

    Sho Ohta, Young Rae Ji ... Doris K Wu
    Emx2 is not required for sibling HCs to acquire their designated locations within the neuromast, inferring that Emx2 mediates opposite HC orientation by changing location of hair bundle establishment.
    1. Cell Biology
    2. Developmental Biology

    Optogenetic investigation of BMP target gene expression diversity

    Katherine W Rogers, Mohammad ElGamacy ... Patrick Müller
    Optogenetic manipulation of BMP signaling indicates that diversity in BMP-dependent gene expression is not well explained by differential responses to BMP, and combinatorial signaling is a major driver of diversity.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Canonical Wnt signaling and the regulation of divergent mesenchymal Fgf8 expression in axolotl limb development and regeneration

    Giacomo L Glotzer, Pietro Tardivo, Elly M Tanaka
    Although many Apical Ectodermal Ridge signaling components are found in the axolotl limb epidermis, responsiveness to canonical Wnt signaling has shifted to the limb mesenchyme where it regulates mesenchymal Fgf8 expression.