156 results found
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection

    Anastasia A Minervina et al.
    Longitudinal tracking of individual T-cell clones reveals the expansion of pre-existing T-cell memory in response to SARS-CoV-2 infection.
    1. Neuroscience

    Multi-contrast anatomical subcortical structures parcellation

    Pierre-Louis Bazin et al.
    An open-source software tool enables the anatomical parcellation of an unprecedented number of subcortical structures in magnetic resonance images of the human brain, automatically and in individual subjects.
    1. Cell Biology
    2. Physics of Living Systems

    Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm

    James F Pelletier et al.
    Live imaging of multiple cytoplasmic networks in frog egg extracts calls for new models for how egg cytoplasm is physically organized during cleavage divisions.
    1. Physics of Living Systems

    Quantitative dissection of transcription in development yields evidence for transcription-factor-driven chromatin accessibility

    Elizabeth Eck et al.
    Confronting different models of chromatin accessibility with temporally resolved transcription profiles favors a scenario where transcription factors actively, rather than passively, drive chromatin from the inaccessible to the accessible state.
    1. Neuroscience

    Three rules govern thalamocortical connectivity of fast-spike inhibitory interneurons in the visual cortex

    Yulia Bereshpolova et al.
    In the visual system, three rules guide the thalamocortical connectivity of cortical fast-spike interneurons and are key to understand the potent and broadly tuned feed-forward inhibition that they generate.
    1. Neuroscience

    Extended field-of-view ultrathin microendoscopes for high-resolution two-photon imaging with minimal invasiveness

    Andrea Antonini et al.
    Aberration correction using 3D microprinting in ultrathin microendoscopes allows two-photon imaging of large neuronal networks with homogeneously high spatial resolution and minimal invasiveness in the deep mouse brain.
    1. Biochemistry and Chemical Biology

    Talin-activated vinculin interacts with branched actin networks to initiate bundles

    Rajaa Boujemaa-Paterski et al.
    At adhesion sites, talin-activated vinculin promotes interactions with the actin network that initiates bundles.
    1. Neuroscience

    The SSVEP tracks attention, not consciousness, during perceptual filling-in

    Matthew J Davidson et al.
    The strength of frequency-tagged neural activity during perceptual filling anti-correlates with the contents of consciousness, yet positively correlates with a neural measure of attention, dissociating these often confounded brain processes.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Evolution of multicellularity by collective integration of spatial information

    Enrico Sandro Colizzi et al.
    Selection for undifferentiated multicellularity emerges in an evolutionary cell-based model because a collective of cells performs chemotaxis better than single cells in a noisy environment.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Arrayed CRISPRi and quantitative imaging describe the morphotypic landscape of essential mycobacterial genes

    Timothy J de Wet et al.
    A high-throughput functional genomics approach combining inducible CRISPR-interference and quantitative imaging yields an atlas of 'phenoprints' to guide gene function assignments, identify metabolic pathway-specific morphotypes, and inform antibiotic mechanism-of-action studies.

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