487 results found
    1. Cell Biology
    2. Cancer Biology

    Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer

    Keren Yizhak et al.
    Genome-scale metabolic modeling of individual cancer cells and healthy human cells identifies specific and selective metabolic vulnerabilities.
  1. Research: Theory, models and biology

    Wenying Shou et al.
    Theoretical ideas have a rich history in many areas of biology, and new theories and mathematical models have much to offer in the future.
    Editorial
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  2. Philosophy of Biology: The challenges of big data biology

    Sabina Leonelli
    Understanding how data were collected and processed is an essential element of big data biology.
    1. Computational and Systems Biology

    Synthetic Biology: Minimal cells, maximal knowledge

    Jean-Christophe Lachance et al.
    Modeling all the chemical reactions that take place in a minimal cell will help us to understand the fundamental interactions that power life.
    Insight
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    1. Neuroscience

    A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

    June K Corrigan et al.
    The metabolic rate of mice is disproportionately affected by the site of experimentation, affecting the phenotypic interpretation of genetically modified strains.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Chromatin accessibility dynamics and single cell RNA-Seq reveal new regulators of regeneration in neural progenitors

    Anneke Dixie Kakebeen et al.
    Regenerating neural progenitors of the Xenopus tropicalis tail prioritize differentiation to motor neuron types earlier than proliferation, a decision partly regulated by the transcription factors Pbx3 and Meis1.
    1. Cell Biology

    Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment

    Leilei Zhong et al.
    A newly identified adipose lineage cell population, MALP, regulates marrow vasculature and osteogenesis in bone.
    1. Ecology
    2. Epidemiology and Global Health

    Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence

    Cara E Brook et al.
    Bats' uniquely robust innate antiviral immune defenses select for faster transmitting viruses likely to generate extreme virulence upon spillover to secondary hosts with immune systems divergent from those of bat.
    1. Computational and Systems Biology
    2. Neuroscience

    Tuning movement for sensing in an uncertain world

    Chen Chen et al.
    Animals work in a world full of surprises, where using energy to position sensors proportional to the location's expected information avoids the pitfalls of positioning them at the information maxima.
    1. Evolutionary Biology

    Convergent changes in muscle metabolism depend on duration of high-altitude ancestry across Andean waterfowl

    Neal J Dawson et al.
    Changes in pathways of lipid oxidation, glycolysis, and mitochondrial oxidative phosphorylation are common strategies to cope with high-altitude hypoxia, but some changes require longer evolutionary time to arise.

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