1,364 results found
    1. Cancer Biology
    2. Cell Biology

    Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

    Hao Zeng et al.
    Functional genomic screening reveals new synthetic lethality with and modes of resistance to epidermal growth factor receptor (EGFR) targeted therapy in EGFR-mutant human lung cancer.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells

    Raghuvir Viswanatha et al.
    Pooled CRISPR knockout screening in Drosophila cells enables high-resolution, genome-wide functional genomic comparisons in cell-lines across vast evolutionary distance.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Genetic interactions of G-quadruplexes in humans

    Katherine G Zyner et al.
    For the first time, the spectrum of genes and pathways interacting with alternative DNA structures called G-quadruplexes in humans is revealed highlighting new possibilities for the pursuit of cancer therapies.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62

    Rowena DeJesus et al.
    FACS-based pooled CRISPR screening is a powerful forward genetic tool to interrogate cellular pathways and targets that modulate protein fate.
    1. Cell Biology

    Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells

    Maxence Le Vasseur et al.
    OCIAD1 associates with prohibitin assemblies and regulates the proteolytic processing and stability of the catalytical Complex III subunit cytochrome c1.
    1. Computational and Systems Biology

    Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin

    Lucile Megret et al.
    Cell-type-specific molecular systems mapping reveals that striatal neuron degeneration in Huntington's disease is primarily driven by the loss of homeostatic responses.
    1. Neuroscience

    Homeostatic plasticity fails at the intersection of autism-gene mutations and a novel class of common genetic modifiers

    Özgür Genç et al.
    Forward genetic screens define a novel genetic landscape by which diverse, unrelated autism risk genes may converge to commonly affect the robustness of synaptic transmission.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Damage-responsive, maturity-silenced enhancers regulate multiple genes that direct regeneration in Drosophila

    Robin E Harris et al.
    The reduced ability of Drosophila imaginal discs to regenerate as they mature can be explained by the silencing of damage-responsive enhancers that regulate expression of genes required for regeneration.
    1. Cell Biology

    Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs

    Albert Lu et al.
    A screen using artificially barcoded, exosomal microRNAs, paired with CRISPR guide RNAs, helped identify new players in multivesicular endosome exocytosis and a role for Wnt signaling.
    1. Neuroscience

    Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels

    Hongkang Zhang et al.
    Optogenetic tools enable sophisticated measurements of a voltage-gated sodium channel implicated in pain, as well as high-throughput screening of candidate channel blockers.

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