1,602 results found
    1. Evolutionary Biology

    Recent shifts in the genomic ancestry of Mexican Americans may alter the genetic architecture of biomedical traits

    Melissa L Spear et al.
    Admixture dynamics have recently changed over time in Mexican Americans resulting in an impact on the genetic architecture of phenotypic variation.
    1. Chromosomes and Gene Expression

    A multiplexed DNA FISH strategy for assessing genome architecture in Caenorhabditis elegans

    Brandon D Fields et al.
    The design and validation of an oligo-based DNA FISH library that targets the entire Caenorhabditis elegans genome at chromosome, three megabase, and 500 kb scales.
    1. Evolutionary Biology

    The genetic architecture of gene expression levels in wild baboons

    Jenny Tung et al.
    RNA sequencing of individuals within a wild baboon population reveals extensive power to detect functional regulatory variation, and suggests that the set of genes affected by such variation may be conserved across species.
    1. Developmental Biology
    2. Genetics and Genomics

    A genome engineering resource to uncover principles of cellular organization and tissue architecture by lipid signaling

    Deepti Trivedi et al.
    A genome editing resource for discovering, in Drosophila, the organization of cellular structure and function by phosphoinositide signaling.
    1. Genetics and Genomics

    Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage

    Angela Schulz et al.
    Genetic and functional studies reveal a previously unrecognized role for a transmembrane protein in glomerular filtration barrier function.
    1. Computational and Systems Biology

    The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture

    Athma A Pai et al.
    Surprising connections between gene architecture and splicing kinetics are illuminated using short, progressive metabolic labeling/RNA sequencing and novel computational modeling approaches in Drosophila cells.
    1. Plant Biology

    The genetic architecture of host response reveals the importance of arbuscular mycorrhizae to maize cultivation

    M Rosario Ramírez-Flores et al.
    Heritable variation in the benefit maize plants receive from arbuscular mycorrhizal fungi supports the feasibility of breeding crops to optimize use of this ancient symbiosis.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Genomic architecture and evolutionary antagonism drive allelic expression bias in the social supergene of red fire ants

    Carlos Martinez-Ruiz et al.
    Analyses of allelic- and socially-biased gene expression reveal that suppressed recombination causes most of the expression differences in the social supergene, with only few differences due to socially antagonistic selection.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The genetic architecture of NAFLD among inbred strains of mice

    Simon T Hui et al.
    A system genetics approach reveals a unique molecular signature of non-alcoholic fatty liver disease in mice and identifies novel genetic factors affecting hepatic steatosis.

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