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5,378 results found
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Genetic and epigenetic variation in the lineage specification of regulatory T cells

    Aaron Arvey et al.
    There is limited epigenetic conservation of lineage-specific DNA elements in Treg cells, and genetic variation in Treg cell specific enhancers is associated with autoimmune disease.
    1. Genetics and Genomics

    Passive and active DNA methylation and the interplay with genetic variation in gene regulation

    Maria Gutierrez-Arcelus et al.
    Detailed analysis of umbilical cord cells shows that the associations between DNA methylation, gene expression and genetic variation are complex and context-dependent.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genetics of trans-regulatory variation in gene expression

    Frank Wolfgang Albert et al.
    A genetic mapping study in more than 1000 yeast individuals reveals the complexity of trans-acting genetic influences on transcriptome variation in unprecedented depth and detail.
    1. Cell Biology
    2. Physics of Living Systems

    Non-genetic inheritance restraint of cell-to-cell variation

    Harsh Vashistha et al.
    Quantitative measurement of epigenetic memory and inheritance dynamics.
    1. Genetics and Genomics

    Genetic variation in adaptability and pleiotropy in budding yeast

    Elizabeth R Jerison et al.
    Substantial heritable genetic variation in adaptability and the pleiotropic consequences of adaptation exists in budding yeast, and can be explained by a combination of fitness and specific segregating alleles.
    1. Ecology
    2. Plant Biology

    Natural genetic variation in Arabidopsis thaliana defense metabolism genes modulates field fitness

    Rachel Kerwin et al.
    Environmental heterogeneity may contribute to the high levels of genetic variation in glucosinolate genes found in Arabidopsis thaliana.
    1. Evolutionary Biology

    Host-pathogen coevolution increases genetic variation in susceptibility to infection

    Elizabeth ML Duxbury et al.
    A history of coevolution increases genetic variation in the susceptibility of Drosophila to viruses, largely by introducing major-effect resistance polymorphisms into populations.
    1. Genetics and Genomics
    2. Plant Biology

    Cytoplasmic genetic variation and extensive cytonuclear interactions influence natural variation in the metabolome

    Bindu Joseph et al.
    Genes located within cellular organelles impact phenotype more than expected due to their interactions with nuclear genes.
    1. Genetics and Genomics

    Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster

    Lauren M Dembeck et al.
    Genome wide association analyses in a wild-derived Drosophila melanogaster population uncover extensive variation in cuticular hydrocarbon composition, which may present a target for natural selection and adaptive evolution.
    1. Genetics and Genomics

    Wild worm embryogenesis harbors ubiquitous polygenic modifier variation

    Annalise B Paaby et al.
    Cryptic alleles affecting embryonic development are widespread in wild C. elegans populations.

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