A set of adaptive mutations affect only a small number of phenotypes that matter in the evolution condition, and yet contain substantial latent functional diversity revealed in distant environments.

The mechanistic impact of genetic variants can be combined with previous knowledge on gene function to deliver conditional growth predictions and pave the way for personalized genetic interventions.

Genomics-based evidence support population- and sex-specific selection of an epistatic interaction between genetic variants in ADCY9 and CETP, genes of pharmacogenetic importance in cardiovascular diseases.

Multivariate genotype-phenotype mapping enables quantification of pathway and process-level effects on complex phenotypes and predicts phenotypic effects of novel mutations.

A framework has been devised that enables global participation in the curation of publications on any topic involving two or more living organisms, ranging from microscopic to larger sizes, in their natural or artificial environments or ecosystems.

Large-scale screens and computational approaches reveal phenotypes for 3492 genes and gene-ontology predictions for 783 genes, including hitherto unstudied genes, which provides a potent platform to further dissect protein function.

A novel DNA/RNA modifying enzyme catalyzing a previously unknown 5-carbamoyloxymethylcytosine modification has been discovered using a novel framework called Metagenomics Genome-Phenome Association.

Carriage of MDR S. Typhi H58 sublineages that also cause acute disease provides understanding of the transmission dynamics of typhoid fever and maintenance of local pathogen populations in Kenya children.

A bulk barcoded quantitative trait locus approach increases the power and resolution of genotype-phenotype mapping in yeast, revealing that the genetic architecture of 18 complex traits is highly polygenic, and is characterized by widespread epistatic interactions and pleiotropic effects.

A retracting gradient of the transcription factor Tailless spatiotemporally patterns the Drosophila tail region by modulating the intrinsic dynamics of a regulatory network involving the timer genes caudal, Dichaete, and odd-paired.