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    1. Developmental Biology
    2. Immunology and Inflammation

    T cell self-reactivity during thymic development dictates the timing of positive selection

    Lydia K Lutes et al.
    Developing T cells whose TCRs have relatively low reactivity experience very brief TCR signaling events, experience delayed positive selection, and retaina preselection gene expression signature as they mature.
    1. Physics of Living Systems

    Confinement discerns swarmers from planktonic bacteria

    Weijie Chen et al.
    For the same bacterial strain, the swarming phenotype can be biophysically discerned from swimming phenotype based on the motion pattern under circular confinement on a soft agar.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    ImmunoCluster provides a computational framework for the nonspecialist to profile high-dimensional cytometry data

    James W Opzoomer et al.
    ImmunoCluster permits nonspecialist users to interrogate liquid and imaging mass, and flow cytometry datasets, resolving novel layers of cellular heterogeneity and insight, as well as producing publishable outputs and figures.
    1. Biochemistry and Chemical Biology

    Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine

    Qiang Liu et al.
    Identifying and understanding that local anesthetic dyclonine targets TRPV3 channels will help to conceive therapeutic interventions.
    1. Cell Biology
    2. Developmental Biology

    EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice

    Yuki Osawa et al.
    EXOC1 contributes to the proper differentiation balance of spermatogonial stem cells and spermatocyte syncytia formation by regulating the morphology of male germ cells.
    1. Developmental Biology

    A calcineurin-mediated scaling mechanism that controls a K+-leak channel to regulate morphogen and growth factor transcription

    Chao Yi et al.
    Calcineurin regulates an electrophysiological mechanism that activates the transcription of specific developmental genes in a heirarchical manner to scale fish appendages.
    1. Immunology and Inflammation

    Fate mapping analysis reveals a novel murine dermal migratory Langerhans-like cell population

    Jianpeng Sheng et al.
    Fate mapping analysis shows that not bona fide Langerhans cells but their ‘look-alikes’ dermal Langerhans cell-like cells migrate to the lymph nodes.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    CRISPR-based functional genomics in human dendritic cells

    Marco Jost et al.
    A CRISPR-based method enables targeted knockouts and genetic screens in human dendritic cells.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Morphological and genomic shifts in mole-rat ‘queens’ increase fecundity but reduce skeletal integrity

    Rachel A Johnston et al.
    In cooperatively breeding Damaraland mole-rats, transitioning to 'queen' results in extensive gene regulatory and morphological remodeling, but also costs to skeletal integrity that scale with reproductive investment.