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HepG2 transmitochondrial cybrids of haplogroup J genome had increased sensitivity to aspects of mitochondrial dysfunction induced by tolcapone and 2-hydroxyflutamide, compared to haplogroup H, thus cybrids provide a practical system to investigate the consequences of mitochondrial genome on drug-induced hepatotoxicity.

Embryonic gene expression is strongly influenced by maternal genetic variation and by embryonic variation that acts in cis but not in trans.

A high-throughput analysis of several self-cleaving ribozymes reveals the effect of every possible mutation, and every possible pair of mutations, and how patterns in the relative activity data can be mapped to canonical and non-canonical structural elements.

Enzyme evolution is reversible on a structural and functional (phenotypic) level, but through a different mutational pathway that leads to genotypic incompatibility with the ancestor.

Interferon lambda 4, a protein part of the innate immune response, drives major amino acids selection in patients chronically infected with hepatitis C virus.

Analysis of human cytomegalovirus-encoded glycoprotein US10 targeting human leucocyte antigen class I molecules reveals a multimodal strategy, resulting in a geno- and allotypic-dependent effects.

A new insight into quinoa diversity enables sequence-based breeding and functional genomics.

Genetic variation can have multiple effects on different phenotypic traits in organisms living in the natural environment.

The evolution of insecticide-avoidance behaviour can be used to generate new spatial repellents to keep malaria vectors out of homes.

In large vaccine trials conducted in dengue-endemic Asia and Latin America, the CYD-TDV tetravalent dengue vaccine shows limited variation in intra-serotype efficacy in the target population for vaccination (>9 years).