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    1. Developmental Biology
    2. Physics of Living Systems

    Gene-free methodology for cell fate dynamics during development

    Francis Corson, Eric D Siggia
    Mathematical methods based on geometry that directly embody the developmental concepts of competency, commitment, and determination provide succinct descriptions of morphogenesis and allow quantitative predictions from fits to sparse genetic data in Caenorhabditis elegans.
    1. Physics of Living Systems

    Ciliary chemosensitivity is enhanced by cilium geometry and motility

    David Hickey et al.
    Chemical receptors located on cilia can achieve particle capture rates that are many times higher than receptors located on a flat epithelial surface.
    1. Developmental Biology

    Embryonic geometry underlies phenotypic variation in decanalized conditions

    Anqi Huang et al.
    Gene regulatory networks incorporate information of the embryonic geometrical parameters to give rise to differential individual patterning outputs under decanalized genetics backgrounds.
    1. Cell Biology

    Insights into centriole geometry revealed by cryotomography of doublet and triplet centrioles

    Garrett A Greenan et al.
    Cryo-electron tomography of mammalian and fly centrioles shows that the ninefold symmetry of centrioles is set by species-specific microtubule linkers.
    1. Physics of Living Systems

    The biomechanical role of extra-axonemal structures in shaping the flagellar beat of Euglena gracilis

    Giancarlo Cicconofri et al.
    The 'spinning lasso' geometry of Euglena's beating flagellum is revealed, and a model based on the antagonistic forces exchanged by axoneme and paraflagellar rod is proposed to explain its emergence.
    1. Microbiology and Infectious Disease

    Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in Helicobacter pylori

    Jennifer A Taylor et al.
    The helical bacterium Helicobacter pylori patterns cell wall synthesis using two distinct cytoskeletal proteins, CcmA and MreB, to achieve its characteristic shape.
    1. Computational and Systems Biology
    2. Neuroscience

    Bumblebee visual allometry results in locally improved resolution and globally improved sensitivity

    Gavin J Taylor et al.
    Bigger bumblebee eyes have better vision, yet their field of view, sensitivity, and resolution do not all simply scale up with eye size, being improved locally instead.
    1. Developmental Biology

    Quantification of gene expression patterns to reveal the origins of abnormal morphogenesis

    Neus Martínez-Abadías et al.
    Quantitative analyses associating the morphology of developing organs with dynamic gene expression patterns can reveal biological phenomena that cause malformations and malfunction but remain elusive to traditional qualitative assessments.
    1. Structural Biology and Molecular Biophysics

    Geometry of antiparallel microtubule bundles regulates relative sliding and stalling by PRC1 and Kif4A

    Sithara Wijeratne, Radhika Subramanian
    Geometrical features of microtubule arrays regulate the collective activity of motor and non-motor proteins.
    1. Cell Biology
    2. Plant Biology

    From plasmodesma geometry to effective symplasmic permeability through biophysical modelling

    Eva E Deinum et al.
    A new biophysical model enables the reconciliation of ultrastructural and tissue level measurements on parameters affecting intercellular communication, and provides novel functional insight into experimental findings.