1,243 results found
    1. Genetics and Genomics

    Dynamics and regulatory roles of RNA m6A methylation in unbalanced genomes

    Shuai Zhang, Ruixue Wang ... Lin Sun
    Global analyses using aneuploid Drosophila revealed the dynamic roles of RNA m6A modification in regulating gene expression and development under genomic imbalance, highlighting its potential relationships with dosage-related effects.
    1. Developmental Biology

    Meioc-Piwil1 complexes regulate rRNA transcription for differentiation of spermatogonial stem cells

    Toshihiro Kawasaki, Toshiya Nishimura ... Noriyoshi Sakai
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Solid
    1. Cell Biology
    2. Cancer Biology

    Cell crowding induces TRPV4 inhibition and its relocation to plasma membranes, implicating pro-invasive cell volume reduction mechanotransduction pathway

    Xiangning Bu, Nathanael Ashby ... Inhee Chung
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Developmental Biology

    Knockout of cyclin dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice

    Alexandra V Bruter, Ekaterina A Varlamova ... Victor V Tatarskiy
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Stem Cells and Regenerative Medicine

    Chromatin activity of IκBα mediates the exit from naïve pluripotency

    Luis G Palma, Daniel Álvarez-Villanueva ... Anna Bigas
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross-stage recognition of glutamate-rich repeats

    Axelle Amen, Randy Yoo ... Matthijs M Jore
    A naturally acquired human monoclonal antibody recognizes proteins expressed at different stages of the Plasmodium falciparum life cycle through affinity-matured homotypic interactions with glutamate-rich repeats.
    1. Genetics and Genomics

    3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity

    Khanh B Trang, Matthew C Pahl ... Struan FA Grant
    Integration of GWAS summary statistics with extensive 3D genomic datasets generated in a myriad of different cell types provides genomic insights into pediatric obesity pathogenesis.

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