The scaffolding protein Oskar organizes two types of germ granules by phase transition within the same cell but with distinct morphologies, composition and biological functions.
Genetic and cell biological study indicates that germ cells' connectivity serves as a mechanism to increase the sensitivity of germline to DNA damage, protecting the genome of gametes, in the Drosophila testis.
Megan M Colonnetta, Lauren R Lym ... Girish Deshpande
A molecular duel between germline and somatic determinants ensures proper establishment of transcriptional quiescence in the primordial germ cells of early Drosophila embryos.
Subhradip Das, Sushmitha Hegde ... Girish S Ratnaparkhi
During Drosophila primordial germ cells (PGCs) specification, the centrosome and germplasm are subject to regulation, during the maternal zygotic transition, by Caspar/TER94-dependent degradative pathways that influence PGC determinants.
Increased Notch signaling enhances germ cell reprograming in C. elegans by antagonizing PRC2-mediated repression, which results in the activation of UTX-1 and other reprograming-promoting genes.
Steven A Cincotta, Nainoa Richardson ... Diana J Laird
Although developing oocytes and sperm of mice both harbor the glucocorticoid receptor, fetal oocytes are resistant to differing levels of gluocorcorticoid stress hormones, while spermatogonia alter RNA splicing.
Steven Z DeLuca, Megha Ghildiyal ... Allan C Spradling
Characterization of Drosophila female germ cell differentiation shows that nurse cells initiate Polycomb silencing by regulating Pcl and Scm levels to alter the biochemical properties of the PRC2 H3K27 methylase.
Kyaw Thu Minn, Yuheng C Fu ... Lilianna Solnica-Krezel
Micropatterned differentiation of human ESCs generates gastrulation cell types – germ layers, extraembryonic, and primordial germ cells with primate characteristics – that show conserved sorting behaviors when dissociated and reseeded as single-cell mixture.
