3,834 results found
    1. Neuroscience

    Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing

    Kevin Dorgans et al.
    Molecular, structural and functional diversity of cerebellar granule cell inputs on single molecular layer interneurons extends information processing in feed-forward inhibition microcircuits.
    1. Developmental Biology

    Distinct mesoderm migration phenotypes in extra-embryonic and embryonic regions of the early mouse embryo

    Bechara Saykali et al.
    At gastrulation, mesoderm arises as a migratory germ layer that will participate to both foetal and placental development through region-dependant adaptation of cytoskeleton composition, cell shape and migration mode.
    1. Developmental Biology
    2. Evolutionary Biology

    Resolving homology in the face of shifting germ layer origins: Lessons from a major skull vault boundary

    Camilla S Teng et al.
    Homology of vertebrate skull structures should be based on evolutionary continuity and an appreciation of germ layer origins and inductive signaling in the embryonic head.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures

    Kyaw Thu Minn et al.
    Micropatterned differentiation of human ESCs generates gastrulation cell types – germ layers, extraembryonic, and primordial germ cells with primate characteristics – that show conserved sorting behaviors when dissociated and reseeded as single-cell mixture.
    1. Developmental Biology

    Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning

    Jose L Pelliccia et al.
    Genetic analyses demonstrate that Gdf3/Vg1 is a maternal effect gene required for robust Nodal signaling during different phases of embryogenesis including germ-layer formation, Kupffer's vesicle morphogenesis, and left-right patterning.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states

    Sumin Jang et al.
    Mammalian germ layer differentiation is characterized by transitions through discrete cell states, which are transcriptionally as well as functionally distinct.
    1. Developmental Biology
    2. Evolutionary Biology

    Germ layer-specific regulation of cell polarity and adhesion gives insight into the evolution of mesoderm

    Miguel Salinas-Saavedra et al.
    The expression of 'bilaterian-mesodermal’ genes changes the epithelial properties of the endomesoderm during the embryogenesis of the cnidarian Nematostella vectensis.
    1. Neuroscience

    Deletion of Stk11 and Fos in mouse BLA projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory

    David Levitan et al.
    Stk11 and Fos expression plays an important role in CTA long-term memory formation by modulating the intrinsic excitability of BLApn.
    1. Developmental Biology

    Co-expression of Foxa.a, Foxd and Fgf9/16/20 defines a transient mesendoderm regulatory state in ascidian embryos

    Clare Hudson et al.
    Ascidian mesendoderm is a transient regulatory state upstream of mesoderm and endoderm gene regulatory networks and required for the initiation of both.
    1. Neuroscience

    Balancing model-based and memory-free action selection under competitive pressure

    Atsushi Kikumoto, Ulrich Mayr
    People compete by trying to outsmart their opponents as long as they win, but show random behavior, and neural signs of suppressing knowledge about opponents’ strategies, when they lose.

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