932 results found
  1. eLife Latest: Welcoming our newest editors

    Bringing a broad range of expertise, 113 researchers join eLife’s editorial board as 12 Reviewing Editors move to the leadership team.
    1. Structural Biology and Molecular Biophysics
    2. Biochemistry and Chemical Biology

    Protein polyglutamylation catalyzed by the bacterial calmodulin-dependent pseudokinase SidJ

    Alan Sulpizio et al.
    The pseudokinase-like Legionella effector SidJ catalyzes the glutamylation of bacterial ubiquitin ligases in a calmodulin-dependent manner.
    1. Genetics and Genomics

    An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms

    Oguz Kanca et al.
    Optimization of homology donor DNA production and integration schemes facilitates homologous recombination in vivo and in cell culture in Drosophila melanogaster..
    1. Cell Biology
    2. Evolutionary Biology

    A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization

    Omaya Dudin et al.
    Cellularization in Sphaeroforma arctica generates a self-organized structure that morphologically resembles an epithelium, and is associated with tightly regulated expression of cell adhesion pathways.
    1. Cell Biology

    The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity

    Tsui Han Loo et al.
    The LINC complex, that couples the interphase cytoskeleton to the nucleus, regulates the processing of a cluster of miRNAs required for muscle regeneration by recruiting and interacting directly with Drosha.
    1. Genetics and Genomics

    One-step efficient generation of dual-function conditional knockout and geno-tagging alleles in zebrafish

    Wenyuan Li et al.
    Conditional gene knockout in combination with fluorescent labeling of different alleles can be achieved with high efficiency in zebrafish through NHEJ-mediated targeted insertion using a CRISPR/Cas system.
    1. Biochemistry and Chemical Biology

    Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy

    Benjamin G Horst et al.
    The full-length structures of the mammalian nitric oxide receptor reveal the molecular activation steps and a binding site for the prototype of FDA-approved stimulators.
    1. Cancer Biology
    2. Computational and Systems Biology

    Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

    Amanda B Abildgaard et al.
    Biophysical modeling, performed in silico, can predict the abundance, metabolic stability, and function of MLH1 inside living cells.
    1. Developmental Biology
    2. Genetics and Genomics

    The GATOR complex regulates an essential response to meiotic double-stranded breaks in Drosophila

    Youheng Wei et al.
    The GATOR complex regulates TORC1 activity during meiosis.
  2. Group of raised hands

    Episode 61: October 2019

    In this episode we hear about parents passing on new mutations, a genetic mystery 100 years in the making, the experiences of early-career group leaders, and more.

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