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Stem Cells and Regenerative Medicine
Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters
Ryo Nabeshima et al.
Fam60a, a component of the Sin3a complex, is required for embryonic development and regulates methylation at a subset of gene promoters.
Genetics and Genomics
Human Biology and Medicine
Epigenetic profiling of growth plate chondrocytes sheds insight into regulatory genetic variation influencing height
Michael Guo et al.
Epigenetic profiling of femoral growth plate chondrocytes helps whittle-down GWAS height variants to fewer putative functional variants.
Chromosomes and Gene Expression
Genetics and Genomics
Recurrent gain of function mutation in calcium channel
causes early-onset hypertension with primary aldosteronism
Ute I Scholl et al.
A novel Mendelian disease featuring early-onset hypertension is caused by a recurrent gain of function mutation in
, which encodes the voltage-gated calcium channel Cav3.2.
Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm
Elliot A Perens et al.
The Hand2 transcription factor regulates the dimensions of the kidney by controlling cell fate decisions at the interface between organ fields.
Matrin 3-dependent neurotoxicity is modified by nucleic acid binding and nucleocytoplasmic localization
Ahmed M Malik et al.
The deposition of Matrin 3, a DNA/RNA binding protein implicated in ALS and FTD, results in neurodegeneration dependent upon its localization, self-association, and ability to bind nucleic acids.
Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development
Felipe Mora-Bermúdez et al.
Neural progenitors in humans and chimpanzee organoids show remarkably similar cellular and molecular parameters, but metaphase is longer during human mitosis.
Structural development and dorsoventral maturation of the medial entorhinal cortex
Saikat Ray, Michael Brecht
The medial entorhinal cortex is important for spatial memory formation and matures from dorsal, where smaller spatial-scales are represented, to ventral, where larger spatial-scales are represented.
Neural crest-specific deletion of
in mice leads to craniofacial abnormalities including cleft palate
Dasan Mary Cibi et al.
The identification of the splicing code and all the required components of alternative splicing will be crucial for a comprehensive understanding of this process in the neural crest cell biology.
An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice
João PL Castro et al.
Genome sequencing of mice selected for longer limbs reveals that rapid selection response is due to both discrete loci and polygenic adaptation.
Species-specific maturation profiles of human, chimpanzee and bonobo neural cells
Maria C Marchetto et al.
Using iPSCs as a model to study neurodevelopmental differences between human and nonhuman primates lays the groundwork for understanding aspects of human brain evolution and neurological disease susceptibility.
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