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    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Phylodynamics of SARS-CoV-2 in France, Europe, and the world in 2020

    Romain Coppée, François Blanquart ... Antoine Bridier-Nahmias
    By producing one hundred SARS-CoV-2 phylogenetic trees for different geographical and time scales, the maximum likelihood-based phylodynamic method implemented here enabled to robustly describe SARS-CoV-2 geographic spread through France, Europe, and worldwide in 2020.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    MDverse, shedding light on the dark matter of molecular dynamics simulations

    Johanna KS Tiemann, Magdalena Szczuka ... Pierre Poulain
    Identifying, indexing, and annotating molecular dynamics simulations open data is essential to ensure their proper reuse.
    1. Neuroscience

    Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit

    Alice Gilbert, Xabier Elorza-Vidal ... Martine Cohen-Salmon
    Analysis of a mouse model of megalencephalic leukoencephalopathy with subcortical cysts (MLC) shows that the astrocyte-specific membrane protein MLC1 sustains the postnatal development of perivascular astrocytic processes and that MLC is a developmental disorder of the gliovascular unit.
    1. Plant Biology

    DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis

    Amr Nassrallah, Martin Rougée ... Fredy Barneche
    Light signaling components interact with a histone H2B deubiquitination module, adjusting chromatin states at global level during Arabidopsis seedling development.
    1. Neuroscience

    The BRAIN Initiative data-sharing ecosystem: Characteristics, challenges, benefits, and opportunities

    Sudhanvan Iyer, Kathryn Maxson Jones ... Mary A Majumder
    The BRAIN Initiative data-sharing ecosystem, consisting of seven data archives, faces interoperability and data stewardship challenges but nevertheless offers adaptability to the needs of particular research communities and raw material for network evolution.
    1. Developmental Biology
    2. Neuroscience

    A transcriptome atlas of the mouse iris at single-cell resolution defines cell types and the genomic response to pupil dilation

    Jie Wang, Amir Rattner, Jeremy Nathans
    Using single nucleus RNA sequencing, a complete catalogue of cell types was determined for the mouse iris, and this information was used as a starting point to define the effects of pupil dilation on gene expression and on nuclear morphology.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration

    Camilo Riquelme-Guzmán, Stephanie L Tsai ... Tatiana Sandoval-Guzmán
    In vivo evaluation of mineralized skeleton in the regenerating axolotl limb reveals a significant osteoclast-driven resorption as an early event with long-lasting impact for tissue integration.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular basis of outer kinetochore assembly on CENP-T

    Pim J Huis in 't Veld, Sadasivam Jeganathan ... Andrea Musacchio
    The centromeric protein CENP-T assembles the microtubule-binding interface of kinetochores through direct recruitment of two Ndc80 complexes and indirect recruitment of a third one through the Mis12 complex.
    1. Evolutionary Biology

    Effective population size does not explain long-term variation in genome size and transposable element content in animals

    Alba Marino, Gautier Debaecker ... Benoit Nabholz
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    A stochastic world model on gravity for stability inference

    Taicheng Huang, Jia Liu
    Empirical experiments and computational modeling reveal a stochastic world model on gravity for stability inference that represents gravity’s vertical direction as a Gaussian distribution.