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  1. Mountain climber

    Introducing Innovation Leaders 2020

    We invite you to join our mentorship programme designed for innovators in open science and research communication.
    1. Developmental Biology

    Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in flight muscles

    Florian Schueder, Pierre Mangeol ... Frank Schnorrer
    The two Drosophila titin homologs Sallimus and Projectin display a precise tandem arrangement in the sarcomere that may explain how sarcomere length is regulated outside of vertebrates.
    1. Computational and Systems Biology
    2. Neuroscience

    BrainPy, a flexible, integrative, efficient, and extensible framework for general-purpose brain dynamics programming

    Chaoming Wang, Tianqiu Zhang ... Si Wu
    BrainPy presents a general-purpose programming framework that enables efficient implementation, simulation, training, and analysis of brain dynamics models across multiple organization scales, ultimately facilitating the understanding of the complex neural mechanisms underlying brain functions.
    1. Computational and Systems Biology
    2. Neuroscience

    Disrupting abnormal neuronal oscillations with adaptive delayed feedback control

    Domingos Leite de Castro, Miguel Aroso ... Paulo Aguiar
    Adaptive delayed feedback control is presented as a new real-time, closed-loop control algorithm for neurostimulation which can disrupt oscillations and reduce network synchrony in neuronal populations.
    1. Genetics and Genomics

    The genetic basis for ecological adaptation of the Atlantic herring revealed by genome sequencing

    Alvaro Martinez Barrio, Sangeet Lamichhaney ... Leif Andersson
    Whole genome sequencing of 19 populations of Atlantic and Baltic herring reveals hundreds of individual loci underlying adaptation to a low salinity niche or timing of reproduction.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Two novel, tightly linked, and rapidly evolving genes underlie Aedes aegypti mosquito reproductive resilience during drought

    Krithika Venkataraman, Nadav Shai ... Leslie B Vosshall
    Two novel, tightly linked, and rapidly evolving genes encoding small secreted proteins are necessary for female mosquitoes to protect their retained eggs during extended periods of drought.
    1. Ecology
    2. Evolutionary Biology

    Windborne migration amplifies insect-mediated pollination services

    Huiru Jia et al.
    Delineating Episyrphus balteatus transregional movements and pollination networks advance a deep understanding of its migration ecology and facilitate the design of targeted strategies to conserve and enhance its ecosystem services.
    1. Developmental Biology
    2. Neuroscience

    Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans

    Menghao Lu, Kota Mizumoto
    Genetic analyses revealed the critical role of local Wnt in neuronal patterning by instructing neurite pruning.
    1. Ecology
    2. Evolutionary Biology

    Megafaunal extinctions, not climate change, may explain Holocene genetic diversity declines in Numenius shorebirds

    Hui Zhen Tan, Justin JFJ Jansen ... Frank E Rheindt
    Application of museomics facilitates characterization of the contribution of historical factors to genetic diversity declines in Numenius shorebirds and highlights that extinction of ecosystem-engineering megafauna may have been detrimental for open-landscape species.
    1. Cell Biology
    2. Developmental Biology

    Myofibril diameter is set by a finely tuned mechanism of protein oligomerization in Drosophila

    Nicanor González-Morales, Yu Shu Xiao ... Frieder Schöck
    Myofibril diameter is set by the controlled oligomerization of the PDZ and LIM domain protein Zasp in Drosophila.