Calcium channel blockers accelerate aortic aneurysm and cause premature aortic rupture in a mouse model of Marfan syndrome through protein kinase C-mediated activation of extracellular signal-regulated kinase.
Potential for specific microbiome-directed, MHC-restricted shaping of a commonly selected HIV-specific CD8+ T cell population was suggested by MHC class I yeast display-based peptide screening approaches.
In nematode worms, NSUN-1 methylates ribosomal RNA and influences phenotypes related to aging, stress resistance, germ line development, and cuticle integrity by regulating translation of specific mRNAs.
Brain imaging reveals frequency-dependent lateralized rhythmic finger tapping control by the auditory cortex with left-lateralized control of relative fast and right-lateralized control of relative slow rhythms.
The mechanosensitive potassium channel TRAAK is localized to nodes of Ranvier is mammalian axons where it hyperpolarizes the resting potential and may contribute to mechanical repolarization of neurons.
L. interrogans utilizes endocytic recycling and vesicular transport systems for transcytosis across endothelial or epithelial barrier in blood vessels or renal tubules, which contributes to spreading and transmission of leptospirosis.