610 results found
    1. Stem Cells and Regenerative Medicine

    Activating the regenerative potential of Müller glia cells in a regeneration-deficient retina

    Katharina Lust, Joachim Wittbrodt
    Müller glia cells in the medaka (Oryzias latipes) retina act as lineage restricted progenitors which only regenerate photoreceptors but can be activated to perform as potent stem cells using Sox2.
    1. Neuroscience

    NG2 glial cells integrate synaptic input in global and dendritic calcium signals

    Wenjing Sun et al.
    NG2 glial cells respond to synaptic input with calcium signals in the absence of action potentials and process synaptic depolarizations with somatic and dendritic voltage gated channels.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Stochastic cell-cycle entry and cell-state-dependent fate outputs of injury-reactivated tectal radial glia in zebrafish

    Shuguang Yu, Jie He
    The analysis of injury-reactivated tectal radial glia in zebrafish reveals a stochastic cell-cycle entry and cell-state-dependent regulation of the balance between neurogenesis and gliogenesis.
    1. Stem Cells and Regenerative Medicine

    Systemic and local cues drive neural stem cell niche remodelling during neurogenesis in Drosophila

    Pauline Spéder, Andrea H Brand
    Cross talk between neural stem cells and their glial niche enables the niche to adapt to the evolving needs of the stem cells throughout development.
    1. Stem Cells and Regenerative Medicine

    Tgfb3 collaborates with PP2A and notch signaling pathways to inhibit retina regeneration

    Mi-Sun Lee et al.
    Tgfb3 inhibits Muller glial cell reprogramming and drives Muller cell quiescence in the injured zebrafish retina, thereby inhibiting retina regeneration.
    1. Neuroscience

    A discrete subtype of neural progenitor crucial for cortical folding in the gyrencephalic mammalian brain

    Naoyuki Matsumoto et al.
    Sonic hedgehog signaling is crucial for the self-renewal of outer radial glial cells and gyrus formation of the cerebral cortex in gyrencephalic mammals.
    1. Neuroscience

    Regulation of neuronal axon specification by glia-neuron gap junctions in C. elegans

    Lingfeng Meng et al.
    Genetic study of C. elegans neural development reveals the function of glia-neuron gap junctions in neuronal axon specification, and shows that glial cells regulate neuronal intracellular pathways through gap junctions.
    1. Neuroscience

    PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling

    Estibaliz González-Fernández et al.
    OPC-specific genetic inhibition of Akt upstream and downstream molecules in the mouse, and simultaneous OPC fate analysis reveal that PTEN-AKT-GSK3b forms a persistent negative signaling pathway for OL development, in parallel with the AKT-mTORC1 pathway.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Species and cell-type properties of classically defined human and rodent neurons and glia

    Xiao Xu et al.
    Gene expression and epigenetic profiling of defined cell types in the central nervous system of mouse, rat, and human reveals inter-species and inter-individual differences.
    1. Neuroscience

    Axons: The cost of communication in the brain

    Brian A MacVicar et al.
    Imaging ATP in axons reveals that they rely on glucose from the blood and lactate produced by glial cells as sources of energy.
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