1,898 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Malaria parasite LIMP protein regulates sporozoite gliding motility and infectivity in mosquito and mammalian hosts

    Jorge M Santos et al.
    A small surface protein regulates gliding motility and host cell invasion by the sporozoite stage of the malaria parasite.
    1. Cell Biology

    Intraflagellar transport drives flagellar surface motility

    Sheng Min Shih et al.
    The transport of proteins along flagellar microtubules generates the force that enables flagella to propel cells across surfaces.
    1. Microbiology and Infectious Disease

    Longitudinal analysis of Plasmodium sporozoite motility in the dermis reveals component of blood vessel recognition

    Christine S Hopp et al.
    Malaria parasites enter the host via the skin, where they are inoculated by an infected mosquito as it probes for blood: the inoculation site is a bottleneck for the parasite and the only time when the parasite is extracellular for more than a few minutes, thus possibly presenting the best opportunity for antibody-mediated inhibition of infection.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding

    Tatyana Bodrug et al.
    Biochemical, single molecule, cell and structural biology studies reveal an interaction between the kinesin-5 tail and motor domains regulating high-force production, which is critical for microtubule sliding motility.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites

    Yong H Woo et al.
    Analysis of chromerid algal genomes reveals how apicomplexans have evolved from free-living algae into successful eukaryotic parasites via massive losses and re-inventing functional roles of genes.
    1. Microbiology and Infectious Disease

    Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP

    Dennis Klug et al.
    Exchange of the I domain in the Plasmodium surface protein TRAP against evolutionary distant I domains rescues infectivity of sporozoites.
    1. Cell Biology
    2. Evolutionary Biology

    A flagellate-to-amoeboid switch in the closest living relatives of animals

    Thibaut Brunet et al.
    The closest living relatives of animals, the choanoflagellates, switch from a flagellate to an amoeboid phenotype under confinement.
    1. Computational and Systems Biology
    2. Neuroscience

    A taxonomy of seizure dynamotypes

    Maria Luisa Saggio et al.
    Taxonomy of seizure dynamics (TSD) provides a rigorous method for classifying and quantifying seizures and a principled framework for understanding seizure initiation and propagation.
    1. Cell Biology

    Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

    Xin Rong et al.
    The enzyme Lpcat3 plays a unique role in the incorporation of arachidonic acid into membranes, which is required for the production of lipoproteins.
    1. Cell Biology

    Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

    Abril Angélica Escamilla-Ayala et al.
    Super-resolution microscopy sets a new strategy to comprehend the membrane organization of γ-secretase at single complex resolution identifying nanodomain associations and its diffusion in situ in the living membrane.

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