148 results found
    1. Cell Biology
    2. Immunology and Inflammation

    Loss of Mir146b with aging contributes to inflammation and mitochondrial dysfunction in thioglycollate-elicited peritoneal macrophages

    Andrea Santeford et al.
    MicroRNA-146b regulates aging, activation, and mitochodrial function in thioglycollate-elicited peritoneal macrophages.
    1. Cancer Biology

    NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

    Carolina Marques et al.
    Neurofibromatosis type 1 gene (NF1) signaling is causally linked to the acquisition of a mesenchymal gene expression program in gliomas through the regulation of the AP-1 transcription factor FOSL1.
    1. Cancer Biology
    2. Medicine

    Association of human breast cancer CD44-/CD24- cells with delayed distant metastasis

    Xinbo Qiao et al.
    CD44-/CD24- breast cancer cells contribute to delayed postoperative distant metastasis by their spontaneous conversion into CD44+/CD24- breast cancer stem cells (CSCs).
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Expanding the MECP2 network using comparative genomics reveals potential therapeutic targets for Rett syndrome

    Irene Unterman et al.
    A novel comparative genomics framework identifies MECP2 network proteins targeted by existing drugs, with three drugs validated in an in vitro Rett syndrome model.
    1. Microbiology and Infectious Disease

    A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma

    Dayana C Farhat et al.
    The epitranscriptomic-driven mRNA polyadenylation pathway protects transcriptome integrity by restricting transcriptional read-throughs and RNA chimera formation in apicomplexan parasites and plants.
    1. Cell Biology
    2. Genetics and Genomics

    Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

    Jiajia Ma et al.
    The serine protease Matriptase orchestrates simultaneous epithelial cell motility and inflammation in pathological states through respective activation of the MAPK pathway and generation of hydrogen peroxide.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide

    Robert P Fuchs et al.
    DNA lesions formed by alkylating agents trigger double-strand breaks, in the absence of replication, by the action of MMR and BER at nearby O-alkyl and N-alkyl adducts, respectively.
    1. Cancer Biology

    Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor

    Qiaoling Liu et al.
    EXOSC1 acts as an endogenous source of mutation inkidney renalclear cell carcinoma via cleaving single-stranded DNA.
    1. Cell Biology
    2. Developmental Biology

    Apical PAR complex proteins protect against programmed epithelial assaults to create a continuous and functional intestinal lumen

    Maria Danielle Sallee et al.
    During intestinal development, apical PAR complex proteins keep apical domains and junctions continuous between cells as they divide and elongate, and ultimately build a continuous functional tube.
    1. Cancer Biology

    Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction

    M Ines Pascoal Ramos et al.
    NC410, a LAIR-2 Fc protein blocking LAIR-collagen interaction, might be a powerful new strategy for cancer immunotherapy for collagen-rich immune-excluded tumors.

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