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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures reveal opening of the store-operated calcium channel Orai

    Xiaowei Hou, Shana R Burstein, Stephen Barstow Long
    The structure of the calcium channel Orai in an open conformation reveals a dilated pore and gives insight into mechanisms of ion permeation and calcium selectivity.
    1. Neuroscience

    Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice

    Christian Thome, Jan Maximilian Janssen ... Maren Engelhardt
    With the new Ankyrin-G-GFP reporter line, researchers can visualize and study neuronal compartments critical for signal transduction without affecting neuronal activity and subcellular integrity of the cells under investigation.
    1. Biochemistry and Chemical Biology

    SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function

    Kate E Coleman, Miklós Békés ... Tony T Huang
    Aberrant neddylation of non-cullin substrates disrupts normal cell cycle progression.
    1. Neuroscience

    Role of the postinspiratory complex in regulating swallow–breathing coordination and other laryngeal behaviors

    Alyssa Huff, Marlusa Karlen-Amarante ... Jan-Marino Ramirez
    The postinspiratory complex acts as an interface between the swallow pattern generator and the preBötzinger complex to coordinate swallow and breathing.
    1. Developmental Biology
    2. Neuroscience

    Synapse weakening-induced caspase-3 activity confers specificity to microglia-mediated synapse elimination

    Zhou Yu, Andrian Gutu ... Erin K O’Shea
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation

    Elizabeth C Marin, Billy J Morris ... Gregory SXE Jefferis
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Neuroscience

    Non-Hebbian plasticity transforms transient experiences into lasting memories

    Islam Faress, Valentina Khalil ... Sadegh Nabavi
    The process of transformation of a transient experience into a memory is neither restricted to the time of the experience nor to the synapses triggered by it, but it can be influenced by past and future events.
    1. Plant Biology

    Domestication and lowland adaptation of coastal preceramic maize from Paredones, Peru

    Miguel Vallebueno-Estrada, Guillermo G Hernández-Robles ... Rafael Montiel
    Ancient maize (~6700-5000 BP) from Paredones, Peru, originated in Mesoamerica, suffered a rapid domestication process, and fast coastal migration to Peru, involving adaptation to both Mesoamerican and South American lowlands with no relevant introgression from teosinte mexicana.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Conserved biophysical compatibility among the highly variable germline-encoded regions shapes TCR-MHC interactions

    Christopher T Boughter, Martin Meier-Schellersheim
    A comprehensive computational study of germline-encoded T cell receptor CDR loops and MHC alpha-helices finds limited evidence for evolutionary conserved interactions, and instead suggests broad biophysical compatibility guides the interactions between the two proteins.
    1. Neuroscience

    Post-ejaculatory Inhibition of Female Sexual Drive via Heterogeneous Neuronal Ensembles in the Medial Preoptic Area

    Kentaro K Ishii, Koichi Hashikawa ... Garret D Stuber
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling