3,274 results found
    1. Cell Biology
    2. Computational and Systems Biology

    Decoupling global biases and local interactions between cell biological variables

    Assaf Zaritsky, Uri Obolski ... Gaudenz Danuser
    DeBias is a generic method to decompose and quantify the confounding, global factors and direct interactions of pairwise interacting variables.
    1. Neuroscience

    Local cortical desynchronization and pupil-linked arousal differentially shape brain states for optimal sensory performance

    Leonhard Waschke, Sarah Tune, Jonas Obleser
    The momentary levels of local cortical desynchronization and pupil-linked arousal pose dissociable influences not only on the processing of sensory information but also on human perceptual performance.
    1. Neuroscience

    State-dependent geometry of population activity in rat auditory cortex

    Dmitry Kobak, Jose L Pardo-Vazquez ... Alfonso Renart
    Representation of sound lateralisation and intensity by neural population in the rat auditory cortex strongly depends on the brain state suggesting that the neural tuning to lateralisation is not hard-wired.
    1. Neuroscience

    Threat of shock increases excitability and connectivity of the intraparietal sulcus

    Nicholas L Balderston, Elizabeth Hale ... Christian Grillon
    Multimodal neuroimaging was used to study the effect of threat on spontaneous brain activity and functional connectivity, and demonstrated that threat increases both activity and connectivity of the intraparietal sulcus, a key node in the frontoparietal attention network.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Chromatin signature of widespread monoallelic expression

    Anwesha Nag, Virginia Savova ... Alexander A Gimelbrant
    Active and repressive chromatin marks, asymmetrically distributed between alleles, distinguish gene bodies subject to epigenetically controlled monoallelic expression on autosomes in human cells.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Global distribution maps of the leishmaniases

    David M Pigott, Samir Bhatt ... Simon I Hay
    Maps defining environmental risk of the leishmaniases provide insights into the ecology of these diseases and identify regions to target public health measures and inform future burden estimates.
    1. Microbiology and Infectious Disease

    Codon usage bias controls mRNA and protein abundance in trypanosomatids

    Laura Jeacock, Joana Faria, David Horn
    Global relative mRNA and protein abundance in trypanosomatids can be effectively estimated at transcriptomic and proteomic scales based on protein-coding sequences alone.
    1. Cancer Biology

    Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

    James Boot, Gabriel Rosser ... Silvia Marino
    A proportion of glioblastoma with global hypo-methylation are enriched for an astrocytic signature and display increased invasion and altered immune landscape.
    1. Ecology

    Global gradients in intertidal species richness and functional groups

    Jakob Thyrring, Lloyd S Peck
    No discernible latitudinal diversity gradient in rocky intertidal α-diversity as local-scale physical and biological processes outweigh global-scale environmental gradients.
    1. Neuroscience

    Functional gradients in the human lateral prefrontal cortex revealed by a comprehensive coordinate-based meta-analysis

    Majd Abdallah, Gaston E Zanitti ... Demian Wassermann
    A comprehensive meta-analysis of the neuroimaging literature reveals that the lateral prefrontal cortex of humans is mainly organized along its rostrocaudal axis according to a unimodal-to-transmodal pattern of network connectivity and a concrete-to-abstract axis of functional associations.

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