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    1. Genetics and Genomics
    2. Immunology and Inflammation

    Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal care

    Xinjian Ye, Yijing Bai ... Qianming Chen
    Mendelian randomization and transcriptome-wide association studies delineate the causal relationships and genetic markers between circulating immune cells and periodontitis, pinpointing neutrophils as the predominant contributors.
    1. Epidemiology and Global Health

    Population-based sequencing of Mycobacterium tuberculosis reveals how current population dynamics are shaped by past epidemics

    Irving Cancino-Muñoz, Mariana G López ... Iñaki Comas
    Low-burden does not mean low local transmission, and tailor-made strategies are needed to control TB based on the knowledge of the local transmission dynamics.
    1. Microbiology and Infectious Disease

    The antigenic switching network of Plasmodium falciparum and its implications for the immuno-epidemiology of malaria

    Robert Noble, Zóe Christodoulou ... Mario Recker
    The first comprehensive analysis of antigenic switching in the malaria-causing parasite Plasmodium falciparum provides new insights into the process that prevents individuals from acquiring immunity to the disease.
    1. Cell Biology

    MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass

    Ellen Phillips, Naseer Ahmad ... Deborah L Johnson
    Identification of a novel role for the transcriptional repressor, MAF1, and RNA polymerase III-dependent transcription, in osteoblast differentiation, mineralization, and bone biology.
    1. Neuroscience

    Hippocampal ensemble dynamics timestamp events in long-term memory

    Alon Rubin, Nitzan Geva ... Yaniv Ziv
    Temporally close events share a common timestamp regardless of the spatial context in which they occur.
    1. Neuroscience

    Decoupling sensory from decisional choice biases in perceptual decision making

    Daniel Linares, David Aguilar-Lleyda, Joan López-Moliner
    Perceptual decision making, even in simple scenarios, is affected by sensory and decisional choice biases.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Global donor and acceptor splicing site kinetics in human cells

    Leonhard Wachutka, Livia Caizzi ... Patrick Cramer
    Transient transcriptome sequencing and kinetic modeling suggest how the kinetics and yield of RNA splicing are encoded in the human genome.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes

    Megan E Carey, Zoe A Dyson ... Global Typhoid Genomics Consortium Group Authorship
    An analysis of the largest Salmonella Typhi genome collection to date (n=13,000) provides an updated overview of global genome diversity and antimicrobial resistance trends over time to inform public health action.
    1. Neuroscience

    Complexity of frequency receptive fields predicts tonotopic variability across species

    Quentin Gaucher, Mariangela Panniello ... Kerry MM Walker
    The A1 of ferrets and mice show similar tonotopic organizations, with neurons preferring a single frequency being more precisely organized into a tonotopic map than multipeaked neurons.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Genomic epidemiology of the first two waves of SARS-CoV-2 in Canada

    Angela McLaughlin, Vincent Montoya ... Jeffrey B Joy
    Canadian COVID-19 travel restrictions imposed in March 2020 greatly reduced SARS-CoV-2 importations, but were insufficient to prevent new sublineages of similar transmissibility from being introduced and replacing early sublineages.